Kovács / Alexander / Bacq The Biochemistry of Poliomyelitis Viruses

A Synopsis of Poliomyelitis Infection and Research
1. Auflage 2014
ISBN: 978-1-4831-5033-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 284 Seiten, Web PDF

The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended. This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.

Autoren/Hrsg.

Kovács, Ernest

Alexander, P.

Bacq, Z. M.

Inhaltsverzeichnis

1;Front Cover;1
2;The Biochemistry of Poliomyelitis Viruses;4
3;Copyright Page ;5
4;Table of Contents;8
5;FOREWORD;12
6;ACKNOWLEDGEMENTS;12
7;CHAPTER 1. THE VIRUSES ;14
7.1;A. Virus in older definitions;14
7.2;B. Virus as it looks now;15
7.3;References to Chapter 1;23
8;CHAPTER 2. THE BIOLOGICAL, BIOCHEMICAL AND EPIDEMIOLOGICAL ASPECTS OF POLIOMYELITIS OF MAN AND ANIMALS;27
8.1;1. General notions;27
8.2;2. Clinical poliomyelitis;28
8.3;3. Biochemical aspects;30
8.4;References to Chapter 2;36
9;CHAPTER 3. EXPERIMENTAL POLIOMYELITIS;39
9.1;1. The disease in animals;39
9.2;2. Isolation of the poliomyelitis virus and its bioassay;41
9.3;Some Aspects of the Immunology and Serology of Poliovirus;46
9.4;References to Chapter 3;48
10;CHAPTER 4. BIOCHEMICAL DATA ON POLIOVIRUS;51
10.1;Purification, crystallization, biochemical and biophysical characterization of poliomyelitis viruses;51
10.2;References to Chapter 4;71
11;CHAPTER 5. BIOCHEMISTRY OF ANIMAL-ADAPTED POLIOMYELITIS INFECTION, in Vivo;75
11.1;Introduction;75
11.2;Respiration and glycolysis;76
11.3;Phosphate metabolism and change in the activity of oxidative enzymes;77
11.4;Biochemical data of chromatolytic neurons and virus infected tissues;78
11.5;Further intracellular localization of virus growth;81
11.6;The role of nutrition and co-factors;82
11.7;The application of enzyme inhibitors;83
11.8;Environmental conditions and conditional factors;83
11.9;Effect of hormones;84
11.10;Data on the effect of X-ray radiation, physical and chemical agents;84
11.11;References to Chapter 5;87
12;CHAPTER 6. FURTHER CONSIDERATIONS OF THE GENERAL BIOLOGY, BIOCHEMISTRY AND PATHOLOGY OF EXPERIMENTAL POLIOMYELITIS INFECTION IN ANIMALS;91
12.1;1. Nucleic acid of the host and the virus during experimental poliomyelitis, in vivo;91
12.2;2. Complementary data on the biology of animal infection;94
12.3;References to Chapter 6;99
13;CHAPTER 7. THE HOST CELLS IN GENERAL;101
13.1;1. General properties of the cells in culture in vitro;101
13.2;2. Light microscopic cytopathic changes due to the poliovirus infection;107
13.3;3. Some facts on the cellular organization as revealed by ultrastructural research;107
13.4;References to Chapter 7;114
14;CHAPTER 8. SOME CYTOLOGICAL AND BIOLOGICAL EFFECTS OF POLIOMYELITIS VIRUS ON CELLS IN CULTURE;117
14.1;1. General notions;117
14.2;2. Changes in cell morphology;118
14.3;3. General biological observations and use of special techniques;119
14.4;References to Chapter 8;123
15;CHAPTER 9 . BIOCHEMISTRY OF POLIOVIRUS INFECTION IN CELLS IN CULTURE;125
15.1;General notions, respiration and glycolysis;125
15.2;References to Chapter 9;139
16;CHAPTER 10. CHANGE IN THE PHYSIOLOGY OF CELLS DURING POUOVIRUS INFECTION, in vitro;141
16.1;1. Further data on biochemical and especially enzyme changes in the host cells;141
16.2;2. Early irreversible enzyme alterations leading to the destruction of the host;149
16.3;3. The influence of hormones and other biological agents administered in vitro;153
16.4;References to Chapter 10;156
17;CHAPTER 11. THE ROLE OF HEREDITY;158
17.1;1. Genetic aspects of clinical and experimental poliomyelitis;158
17.2;2. Virus genetics;161
17.3;3. Hypotheses on the biochemical mechanism of heredity;163
17.4;References to Chapter 11;166
18;CHAPTER 12. FURTHER CONSIDERATIONS ON THE EPIDEMIOLOGY AND IMMUNOLOGY OF POLIOMYELITIS INFECTION;168
18.1;1. General notions;168
18.2;2. The question of immunity against poliomyelitis;172
18.3;3. Defence against poliomyelitis and the efforts for the prevention of the disease;173
18.4;References to Chapter 12;177
19;CHAPTER 13. FACTS AND SPECULATIONS ON THE BIOSYNTHESIS OF THE POLIOVIRUS, A WORKING HYPOTHESIS OF THE AUTHOR;181
19.1;References to Chapter 13;189
20;CHAPTER 14. CHEMICAL, PHYSICAL AND BIOLOGICAL FOUNDATION OF VIRUS RESEARCH;191
20.1;1. Essential notions of nucleic acid and protein biochemistry;191
20.2;2. Chemical structure and biochemistry of proteins;200
20.3;3. Biosynthesis of the proteins and nucleic acids;205
20.4;4. Nucleic acid synthesis in animal systems;211
20.5;References to Chapter 14;214
21;CHAPTER 15. THE BIOCHEMICAL CONCEPT OF POLIOMYELITIS VIRUS INFECTION;219
21.1;References to Chapter 15;230
22;CHAPTER 16. BIOCHEMICAL ASPECTS OF SOME OTHER FEATURES OF THE VIRUS PROBLEM;232
22.1;Virology and tumors;232
22.2;References to Chapter 16;238
23;CHAPTER 17. RECENT DEVELOPMENTS IN POLIOMYELITIS RESEARCH;239
23.1;References to Chapter 1 7;248
24;CHAPTER 18. DISCUSSION AND CONCLUSIONS;251
25;Author Index;256
26;Subject Index;274
27;OTHER TITLES IN THIS SERIES;284