Extracellular Vesicle-Based Biovectors for Diagnostic and Biomedical Applications

Erscheinungsjahr 2026
ISBN: 978-0-443-36641-3
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Extracellular Vesicle-Based Biovectors for Diagnostic and Biomedical Applications provides comprehensive coverage on not only the biosynthesis, isolation, purification, and functionalization of extracellular vesicles for therapeutic and diagnostic applications, but it also explores the current trends of functionalized extracellular vesicles for biomedical research and for commercial-scale opportunities. Organized into three main parts, the book takes a structured approach. Part I focuses on the fundamental aspects of extracellular vesicles, covering their origin, classification, biosynthesis, isolation techniques, purification challenges, and functionalization for biomedical applications. Part II delves into the therapeutic applications of extracellular vesicles and their role in treating diseases, while also addressing biocompatibility, safety, and translation challenges., while also addressing biocompatibility, safety, and translation challenges. Part III explores the diagnostic potential of extracellular vesicles in biomedical research, highlighting their role as diagnostic biomarkers in various diseases. It also discusses emerging technologies and the future directions in extracellular vesicle research. Extracellular Vesicle-Based Biovectors for Diagnostic and Biomedical Applications is a valuable reference for researchers and clinicians seeking an in-depth understanding of extracellular vesicles and their potential biomedical applications.

Autoren/Hrsg.

Kumar, Arun

Singh, Charan

Kaushik, Ajeet Kumar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Medizinische Diagnose und Diagnostik

Inhaltsverzeichnis

Part I: Introduction: Extracellular vesicles origin, classifications and biosynthesis, isolation approaches, purification, and functionalization of extracellular vesicles for biomedical applications and new perspectives
1. Introduction to extracellular vesicles: origin, classification, and biosynthesis
2. Isolation, purification, and challenges in extracellular vesicles
3. Characterization of extracellular vesicles: techniques and technologies
4. Drug loading techniques for extracellular vesicles for biomedical applications
5. Functionalization of extracellular vesicles for biomedical applications

Part II: Therapeutic applications of extracellular vesicles
6. Extracellular vesicles in musculoskeletal and cardiovascular applications
7. Extracellular vesicles in neurodegenerative diseases
8. Extracellular vesicles in autoimmune diseases and immunotherapy
9. Extracellular vesicles in diabetes mellitus and metabolic syndrome
10. Extracellular vesicles in cancer therapy
11. Emerging applications of extracellular vesicles in regenerative medicine and tissue engineering
12. Biocompatibility, safety, and challenges in commercial, regulatory, and clinical translation

Part III: Diagnostic applications of extracellular vesicles in biomedical research
13. Extracellular vesicles as diagnostic biomarkers in cancer research
14. Extracellular vesicles in the diagnosis of diabetes mellitus and associated complications
15. Diagnostic application of extracellular vesicles as biomarkers in neurological disorders
16. Prognostic and diagnostic applications of extracellular vesicles in cardiovascular diseases
17. Extracellular vesicles in the diagnosis of autoimmune diseases
18. Emerging technologies and future directions in extracellular vesicle research

Über Autor(innen)

Singh, Charan
Dr. Charan Singh is currently an Assistant Professor of Pharmaceutics at HNB Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, India. He received his PhD in Pharmaceutical Technology (Formulation) from the National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India. He was later a National Postdoc Fellow at Panjab University, Chandigarh, India and an IBRO-Exchange Fellow at the University of Queensland in Brisbane, Australia. He has received a number of other fellowships and awards such as the IBRO Early Career Award and the SERB-SIRE Fellowship. Dr. Singh's research interests include the design, synthesis, characterization, and evaluation of lipidic and polymeric nanomaterials for drug delivery and targeting to improve the treatment and diagnosis of human diseases. Dr. Singh has one patent (granted) and has published book chapters and more than 50 publications in international journals such as Journal of Controlled Release, Asian Journal of Pharmaceutical Sciences, Carbohydrate Polymers, Drug Delivery Sciences and Technology, International Journal of Pharmaceutics.

Kumar, Arun
Dr. Arun Kumar is currently an Assistant Professor in the Department of Pharmacy at Central University of South Bihar, Gaya, India. He earned a PhD from the Department of Pharmacy at Jaypee University of Information Technology, Waknaghat, Solan, India. He has more than 11 years of combined research and teaching experience, and his work focuses on smart and responsive materials, 3D printing, microneedles, extracellular-based drug delivery, antimicrobial compounds, and nanostructures for various biomedical applications, including tissue regeneration, drug delivery, and cancer therapy. He has actively collaborated with researchers in other disciplines of pharmaceutical sciences, particularly the nanoformulations of drugs for drug delivery systems and nanomedicine. His work has resulted in the publication of over 60 peer-reviewed journal articles in prestigious journals, including International Journal of Biological Macromolecules, Advanced Healthcare Materials, Seminars in Cancer Biology, Journal of Material Chemistry B, and Bioengineering and Translational Medicines. He has also author over five book chapters and has files five patents filed.

Kaushik, Ajeet Kumar
Dr. Ajeet Kaushik is Associate Professor at the NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, USA. He is the recipient of various reputed awards for his service in the area of nano-biotechnology for health care. He has edited seven books, written more than 100 international research peer reviewed publications, and has three patents in the area of nanomedicine and smart biosensors for personalized health care. In the course of his research, Dr. Kaushik has been engaged in the design and development of various electro-active nanostructures for electrochemical biosensor and nanomedicine for health care. His research interests include nanobiotechnology, analytical systems, design and develop nanostructures, nano-carries for drug delivery, nano-therapeutics for CNS diseases, on-demand site-specific release of therapeutic agents, exploring personalized nanomedicines, biosensors, point-of-care sensing devices, and related areas of health care monitoring.