Lehnert Radiosensitizers and Radiochemotherapy in the Treatment of Cancer

Erscheinungsjahr 2014
ISBN: 978-1-4398-2903-5
Verlag: CRC Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 548 Seiten

Reihe: Series in Medical Physics and Biomedical Engineering

Discussing the combined use of chemicals and radiation in the treatments of cancer, this book gathers into a single volume the most up-to-date information on radio sensitizing drugs, the mechanisms of radio sensitization, and the clinical applications of this treatment modality. Written for radiation oncologists, medical oncologists, and residents in various branches of oncology, this text details a range of approaches, agents, and treatment pathways. Intuitively organized by topic and application, it includes the latest clinical trials, extensive illustrations, and a wealth of references.

Zielgruppe

radiation oncologists oncology residents medicinal chemists

Autoren/Hrsg.

Lehnert, Shirley

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

The basics of chemical radiosensitization
Oxygen: the prototypical radiosensitizer
Electron-affinic Radiosensitizers: the NitroimidazoJes and Related Drugs
Hypoxic-specific Cytotoxins
Nitric oxide
Electron-affinic pro-drugs activated by radiation-induced free radicals
The Halogenated pyrimidines. Bromine ands Iodine analogues
Sensitization by suppression of radioprotective substances
Radiosensitizing nucleosides
T opoisomerase inhibitors
Platinum~based drugs
Temolozide (TMZ)
Drugs disrupting microtubule function
Radioprotective Drugs
Targeting EGFR IGF-IR
Targeting Cell-Cycle Checkpoints, DNA Repair and the Proteasome
Targeting HDAC, HSP9Q, P13K and Ras
Targeting the tumor micro-environment: Angiogenesis the tumor vasculature and the HIF proteins
Modulation of radiation response by plant polyphenols
Biological Basis for combining Drugs with Radiation
How Much Radiation is Chemotherapy Worth?
Normal Tissue damage and chemo--radiation
Influence of Fractionation and Dose rate on response to chemoradiation
Radiation~Drug Cross Resistance
Problems of drug delivery for radiosensitizing drugs