Leonard / Bagg Molecular Pathology in Clinical Practice

1. Auflage 2007
ISBN: 978-0-387-33227-7
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 600 Seiten, eBook

Molecular Pathology In Clinical Medicine is an authoritative, comprehensive textbook that provides the general pathologist in clinical practice, as well as residents and fellows during their training, with the current standard in molecular testing. The text is divided into 8 sections, as defined by the molecular pathology specialty board: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. The book integrates the latest advancements in the field with the basic principles and practical applications. Each chapter discusses the clinical significance of each diagnostic test, available assays, quality control and lab issues, interpretation, and reasons for testing. Chapters cover such topics as HIV, herpes, hepatitis, deafness, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. 189 illustrations, 45 of them in full-color, illustrate the principles outlined in the text. This textbook is a classic in the making and a must-have reference to meet the needs of every pathologist, resident and fellow.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Bagg, Adam

Leonard, Debra G.B.

Inhaltsverzeichnis

Basics of Molecular Biology.- Basics of Molecular Biology.- Molecular Pathology Methods.- Molecular Pathology Methods.- Genetics.- Genetic Counseling.- Pedigree Analysis and Risk Assessment.- Bayesian Analysis.- Developmental Disabilities.- Neuromuscular Diseases.- Molecular Genetic Testing for Metabolic Disorders.- Fibroblast Growth Factor Receptor-Related Skeletal Disorders.- Cystic Fibrosis.- Deafness.- Coagulation Disorders.- Hematologic Disorders: Hemochromatosis, Hemoglobinopathies, and Rh Incompatibility.- Cardiovascular Disease.- Neurodegenerative Disorders.- Skin and Connective Tissue Disorders.- Inherited Cancers.- Inherited Breast Cancer.- Familial Adenomatous Polyposis and Turcot and Peutz-Jeghers Syndromes.- Hereditary Nonpolyposis Colorectal Cancer.- Multiple Endocrine Neoplasia Syndromes.- The Neurofibromatoses.- TP53 Mutation and Li-Fraumeni Syndrome.- von Hippel-Lindau Disease.- Solid Tumors.- Breast Cancer.- Urothelial Carcinoma.- Sarcomas.- Gliomas.- Molecular Detection of Occult Tumor Cells.- Microarray Studies (Beyond Histology).- Neoplastic Hematopathology.- Acute Myeloid Leukemia.- Acute Lymphoblastic Leukemia.- B-Cell Lymphomas.- T-Cell Lymphomas.- Lymphoproliferations of Immunodeficiency.- Myeloproliferative Disorders and Myelodysplastic Syndromes.- Infectious Diseases.- Human Immunodeficiency Virus Type 1.- Hepatitis B and C Viruses.- Viral Infections in Transplant Patients.- Viral Infections of the Central Nervous System.- Sexually Transmitted Diseases.- Respiratory Pathogens.- Bacterial Pathogens.- Mycobacterial Infections.- Identity Testing.- Forensic DNA Typing.- Parentage and Relationship Testing.- Assessment of Chimerism in the Setting of Allogeneic Hematopoietic Cell Transplantation.- Specimen Identification Through DNA Analysis.- HLA Typing.- Molecular HLA Typing.- Laboratory Management Issues.- Molecular Pathology Laboratory Management.- From Research to Clinical Practice.