Hormonal Carcinogenesis II

Proceedings of the Second International Symposium
Softcover Nachdruck of the original 1. Auflage 1996
ISBN: 978-1-4612-7506-0
Verlag: Springer

Buch, Englisch, 500 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 820 g

For those of us who have labored in the field of hormonal carcinogenesis, it has been most gratifying to see its rapid growth and increasing relevance in recent years. Although many factors and forces have contributed to this phenomenon, a few appear particularly significant. Perhaps foremost is the realization that two of the most prevalent cancers which afflict women and men; that is, breast and prostate, have essential hormonal component(s) to their etiologies. This should not surprise us since the high frequency of these cancers in human populations has to date not been attributed to any exogenous physical, environmental, or dietary factor(s). A similar argument may be applied to other less prevalent but equally important cancers including ovarian, endometrial, testicular, cervico­ vaginal, pituitary, thyroid, and sex hormone-associated hepatic neoplasms. The Office of Research on Women's Health and many women's interest groups have been instrumental in fostering research and public awareness on women's cancers. Similar concern is beginning to emerge for solely male cancers by other groups. To illustrate an example of the potential pervasive role of hormones in the human, particularly sex hormones, Figure I depicts the endogenous and known exogenous exposures to estrogens and progestins during a woman's lifetime, which may contribute to increased risk for hormonally-associated cancers. = iii M. A. P. _ GI en 2 PoOlmenopauoal ~ EstrogDn ~ Proge. tln GI en J\ Ovulatory _ 2 Cyel. iii W DES EIP Menotr". 1 Ol,order.

Zielgruppe

Research

Autoren/Hrsg.

Li, Jonathan J.

Li, Sara A.

Sekely, Lea I.

Gustafsson, Jan-Ake

Nandi, Satyabrata

Inhaltsverzeichnis

Introductions.- Introductory Remarks.- Opening Address Important Questions in Women’s Health Research: Determining the Influence of Hormones on Health.- Symposium Presentations Mammary Carcinogenesis: A Unifying Hypothesis.- Regulation of Cytochrome P-450 and Carcinogenesis: Peroxisome Proliferator-Activated Receptor and Dioxin Receptor.- State Of The Art Lectures.- 1 Cell Cycle and Cell Proliferation.- 2 Role of a Cell Cycle Regulator in Hereditary and Sporadic Cancers.- 3 Molecular Cytogenetics of Solid Tumor Progression.- 4 Nucleocytoplasmic Shuttling of Estrogen Receptors Is Blocked by “Pure Antiestrogens”.- I. Epidemiology: Hormonal Cancers.- Causality in Hormone Associated Human Cancers.- 5 Breast Cancer Incidence in Women Exposed to Estrogen and Estrogen-Progestin Replacement Therapy.- 6 Breast Cancer Trends in Women in Sweden, the UK, and the USA in Relation to Their Past Use of Oral Contraceptives.- 7 Gene Expression in Familial Breast Cancer: A Genetic-Epidemiology Study of Premenopausal, Bilateral Breast Cancer.- 2. Breast/Mammary Gland.- The Importance of Human Breast Development in Mammary Carcinogenesis.- 8 Breast Susceptibility to Carcinogenesis.- 9 Hormones, Growth Factors and Gene Expression in Preneoplasias of the Mouse Mammary Gland.- 10 Pathogenesis of Ductal and Lobular Progestin-Induced Mammary Carcinomas in BALB/c Mice.- 3. Endometrium/Uterus.- 11 Is the hsp90 Connection Between Steroid Receptors and Immunosuppressant Binding Immunophilins Involved in the Control of Gene Transcription and Cell Growth?.- 12 Expression and Regulation of 17?-Hydroxysteroid Dehydrogenase Type 1 in Steroidogenic Cells and Estrogen Target Tissues.- Growth Factors in Endometrial Cancer.- 4. Kidney.- 13 Introduction Estrogens and Genitourinary Cancers of Syrian Hamsters.- 14 Interstitial Cell Origin of Estrogen-Induced Kidney Tumors in the Syrian Golden Hamster.- 15 Effects of Estrogens on Microtubule Assembly: Significance for Aneuploidy.- 16 Estrogen Carcinogenesis: A Sequential, Epi-Genotoxic, Multi-Stage Process.- 5. Liver.- Role of Estrogens in Liver Carcinogenesis.- 17 Hormonal Regulation of Hepatic Cell Proliferation and Apoptosis: Implications for Carcinogenesis.- 18 Mechanisms of Tamoxifen-Induced Genotoxicity and Carcinogenicity.- 19 Regulation of Growth-Associated Nuclear Transcription Factors During Growth Hormone-Regulated, Sex Differentiated Rat Liver Carcinogenesis.- 6. Prostate.- 20 Isolation of Differentially Expressed cDNAs from Prostate Cancer Cell Lines Using Differential Display PCR: Identification of an Androgen-Regulated Gene.- 21 Progression of LNCaP Human Prostate Carcinoma Cells: Androgen Receptor Activity and c-myc Gene.- 22 Regulation of Prostatic Growth and Gene Expression: Role of Stroma.- Concluding Remarks.- 23 Sex Hormones and Neoplastic Transformation.- CLINICAL FORUM: Risk and Benefits of Hormone Replacement Therapy and Oral Contraceptive Use.- Therapeutic Implications of Hormone Replacement Therapy and Oral Contraceptives.- 24 Postmenopausal Estrogen-Progestin Therapy in Relation to Cancers of the Endometrium and Breast.- 25 The Use of Hormone Replacement Therapy in Women Previously Treated for Breast Cancer.- 26 Cardioprotection by Hormone Replacement Therapy.- 27 Risk and Benefits of Oral Contraceptives.- 28 Oral Contraceptives and the Risk of Breast and Cervical Cancer.- Communications Session I. Epidemiology, Human Studies.- Some Aspects of Breast Cancer Epidemiology.- Risk of Breast Cancer Associated with Induced Abortion.- Family History of Breast Cancer as a Modifier of Other Risk Factors.- Oral Contraceptive Use and Reproductive Risk Factors for Breast Cancer: A Comparison of Results among Black and White Women.- Patterns of Cancer Mortality in Women Who Had Used Sex Steroid Hormones under Age 60.- Progestogen Use and Risk of Breast Cancer.- Five-Year Survival of Women with Breast Cancer According to Prior Use of Oral Contraceptives.- Plasma Prolactin and IGF-1 Levels in Young, Healthy, Nulliparous Women in Relation to Low Dose Oral Contraceptive Use.- Effect of a Low-Fat Diet on Estrogen and Bile Acid Metabolism in Normal Human Subjects.- Expression of GST? in Breast Cancer and its Relationship with the Expression of Estrogen Receptor and Progesterone Receptor.- p53 and Neu (c-erbB-2) Overexpression in Relation to Risk Factors for Breast Cancer.- Cost Effectiveness of Hormone Replacement Therapy in French Postmenopausal Women.- Tamoxifen Treatment Does Not Induce Endometrial Hyperplasia in Postmenopausal Women.- Uterine Myomas: A Model to Study Hormonal Regulation of Growth Related Genes.- Transforming Growth Factor ?1 Facilitates Cell Proliferation and Invasion in MAT-LyLu Prostatic Cancer Cells.- Quantitative Effects of Antiandrogen Therapy on High-Grade Prostatic Intraepithelial Neoplasia in Radical Prostatectomy Specimens.- Alterations in Circulating Levels of Androgens and PSA During Treatment with Finasteride in Men at High Risk for Prostate Cancer.- Session II. Cell & Molecular Biology, Metabolism.- Effect of Estradiol on MCF-7 Human Breast Cancer Cells: Ultrastructural Studies.- Estradiol and Tamoxifen Induce TGF-?l Gene Expression in Cultured Normal Human Breast Stromal Cells.- Estrogen and Anti-Estrogen Regulation of Amplified erbB2 Gene Expression in Human Breast Cancer Cells.- Evaluation of Conformational Changes in hER-HBD by Pharmacological Dissection of Hormone Dissociation Rates in a Homogeneous Hormone-Binding Assay.- Estradiol Promotion of Size and Number of Hepatic Enzyme-Altered Foci in Rats in the Absence of Cell Proliferation.- Expression of Liver-Enriched Transcription Factors During Progression in the Resistant-Hepatocyte Model.- Nuclear Protein Binding to the AP-1 and CRE Sites During Sex-Differentiated Promotion of Rat Liver Carcinogenesis.- Induction of Endometrial Cancer by Tamoxifen in the Rat.- Mechanisms of Anti-Estrogen and Retinoid Inhibition of Breast Cancer Cell Proliferation.- Bisphenol-A Disturbs Microtubule Assembly and Induces Micronuclei In Vitro.- Natural Estrogens Induce Modulation of Microtubules in Chinese Hamster V79 Cells in Culture.- Induction of Micronucleation, Spindle Disturbances, and Mitotic Arrest in Human Chorionic Villi Cells by 17?-Estradiol, Diethylstilbestrol, and Coumestrol.- Increased Nuclear IGF-I Receptor Level, Coupled with Attenuation in DNA Repair, Plays an Important Role in Estrogen-Induced Carcinogenesis.- Pattern of Reproductive Aging in Female Rats Can Affect Mammary Tumor Incidence.- Antiproliferative Activity of Luteolin, a Naturally-Occurring Edible Plant Flavone, Against Estrone-Induced Cell Proliferation in the Mammary Gland of Noble Rats.- Sex Hormone-Induced Prostatic Carcinogenesis in Noble Rats Involves Genetic Damage and Cell Proliferation.- Catechol Estrogen Analogs as Probes of Estrogen Carcinogenesis.- In-Vitro Metabolites of Coumestrol.