Lipids and Membranes: Dynamics and Interorganelle Lipid Transport

Erscheinungsjahr 2026
ISBN: 978-0-443-43314-6
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

Lipids and Membranes: Dynamics and Interorganelle Lipid Transport, Volume 728 covers lipids, a chemically diverse set of biological molecules subject to rapid metabolism and transport. This dynamic behavior has motivated the development of methods across multiple disciplines for their detection and manipulation. Split into three parts, the book's chapters include topics such as Assay of phospholipid scrambling, Tracking lipid transport with bifunctional lipids, Tracking interorganelle lipid transport using genetically encoded mass tags, Molecular Dynamics Simulation of Lipid and Ligand Binding in ORD Domains, Imaging lipid droplet-organelle membrane contact sites using fluorogenic complementation, Studying interactions of amphipathic helices with lipid droplets, and more.

Additional chapters cover Metabolic labeling of to trace changes in sphingolipid metabolism, Imaging intracellular lipid heterogeneity with fluorogen-activated coincidence sensing, Tagging lipoproteins in mycobacteria, Probes for studying sphingolipid dynamics, Measuring Flipper-TR Lifetime with Multiple Analysis Strategies, Reconstitution approaches to understanding cellular lipid dynamics, Prediction and characterization of the bacterial lipid handling machinery, From Molecular Dynamics to Cryo-EM: Imaging Liposomes in Silico, and much more.

Autoren/Hrsg.

Weitere Mitwirkende

Christianson, David

Allen, Karen N.

Baskin, Jeremy M.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Assay of phospholipid scrambling
Anant K. Menon
2. Tracking lipid transport with bifunctional lipids
Andre Nadler
3. Tracking interorganelle lipid transport using genetically encoded mass tags
Benoit Kornmann
4. Molecular Dynamics Simulation of Lipid and Ligand Binding in ORD Domains
Bruno Mesmin
5. Imaging lipid droplet-organelle membrane contact sites using fluorogenic complementation
Chi-Lun Chang
6. Studying interactions of amphipathic helices with lipid droplets
Fabien Alpy
7. Metabolic labeling of to trace changes in sphingolipid metabolism
Fikadu Tafesse
8. Imaging intracellular lipid heterogeneity with fluorogen-activated coincidence sensing
Itay Budin
9. Tagging lipoproteins in mycobacteria
Jessica Seeliger
10. Probes for studying sphingolipid dynamics
Joost Holthuis
11. Measuring Flipper-TR Lifetime with Multiple Analysis Strategies
Juan Manuel Garcia-Arcos
12. Reconstitution approaches to understanding cellular lipid dynamics
Karin Reinisch
13. Prediction and characterization of the bacterial lipid handling machinery
Laura Massah Kulah Dassama
14. From Molecular Dynamics to Cryo-EM: Imaging Liposomes in Silico
Milka Doktorova
15. Genetic screens for lipid discovery in Drosophila
Raghu Padinjat
16. Imaging interorganelle membrane contact sites using dimerization-dependent fluorescent proteins
Sarah Cohen
17. Organelle-selective labeling of lipids containing azide-fatty acids
Tomonori Tamura
18. Analysis of interorganelle lipid exchange
Vytas Bankaitis
19. Reconstitution of full-length extended synaptotagmin 1 into liposomes for membrane tethering and lipid transfer assays
Xin Bian
20. Use of Small Unilamellar Vesicles to Study the Biochemical Properties of the GRAM Domain of GRAMD1
Yasunori Saheki

Über Autor(innen)

Christianson, David
After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson's research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Baskin, Jeremy M.
Jeremy M. Baskin is Associate Professor, Nancy and Peter Meinig Family Investigator in the Life Sciences, and Director of the Chemistry-Biology Interface Program at Cornell University, with appointments in the Department of Chemistry and Chemical Biology and the Weill Institute for Cell and Molecular Biology. He was born and raised in Montreal, Canada and received his undergraduate education at the Massachusetts Institute of Technology, with a major in Chemistry and minors in Biology and Music. Jeremy carried out Ph.D. studies supported by NDSEG and NSF graduate fellowships in Carolyn Bertozzi's group at the University of California, Berkeley, focusing on development of bioorthogonal chemistries. Jeremy received postdoctoral training in lipid cell biology as a Jane Coffin Childs fellow at Yale University with Pietro De Camilli. Research in the Baskin lab centers on the chemical and cell biology of lipid metabolism and signaling. The Baskin lab exploits bioorthogonal chemistry to develop advanced tools for high-resolution lipid imaging and harnesses optogenetics and protein engineering for the design of membrane editors capable of spatiotemporal manipulation of the lipid composition of cellular membranes. Using these and other approaches, his lab elucidates novel mechanisms underlying physiological and pathological lipid metabolism and signaling events. Jeremy has been the recipient of numerous awards, including Beckman Young Investigator, Sloan Research Fellowship, NSF CAREER, ACS Young Academic Investigator, ASBMB Walter A. Shaw Young Investigator in Lipid Research, ICBS Young Chemical Biologist Award, and ACS Chemical Biology Young Investigator Award. He is currently Associate Editor at Biochemistry.

Allen, Karen N.
Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering