Dna-Encoded Library Technology for Drug Discovery

1. Auflage 2025
ISBN: 978-1-78801-487-8
Verlag: RSC Publishing

Buch, Englisch, 176 Seiten, Format (B × H): 160 mm x 239 mm, Gewicht: 408 g

DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.

This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.

A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.

Autoren/Hrsg.

Liu, Guansai

Krusemark, Casey J

Li, Jin

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

- Overview of Affinity-based DEL Selections with Select Target Types and Achievements

- Machine Learning with DEL Selection Data and for DEL design

- One bead one compound (OBOC) DELs for Biochemical Screens

- Live cell-based DEL Selections

- On-DNA Medicinal Chemistry: Focused libraries, fragment expansion, and hit optimization

- DELs with Covalent Warheads

- Application of DELs for E3 Ligase Ligand and PROTAC development

Über Autor(innen)

Krusemark, Casey J
Purdue University, USA