Makowski Advances in Clinical Chemistry

1. Auflage 2009
ISBN: 978-0-08-095098-3
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 277 Seiten

Volume 47 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.
Leading experts from academia and clinical laboratory science Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Autoren/Hrsg.

Makowski, Gregory

Inhaltsverzeichnis

1;Front Cover;1
2;Advances In Clinical Chemistry;4
3;Copyright;5
4;Contents;6
5;Contributors;10
6;Preface;12
7;Chapter 1: Amyloidosis;14
7.1;1. Abstract;15
7.2;2. Historical Perspective;15
7.3;3. Pathogenesis;16
7.4;4. Diagnosis;27
7.5;5. Classification, Clinical Presentation, and Prognosis of Amyloidosis;33
7.6;6. Treatment;41
7.7;References;49
8;Chapter 2: Urinary Markers in Colorectal Cancer;58
8.1;1. Abstract;58
8.2;2. Introduction;59
8.3;3. Potential Urinary Markers for Colorectal Cancer;60
8.4;4. Analytical Techniques and Data Analysis;63
8.5;5. Conclusions;66
8.6;References;66
9;Chapter 3: Effect of Hormone Replacement Therapy on Inflammatory Biomarkers;72
9.1;1. Abstract;73
9.2;2. Introduction;73
9.3;3. Inflammation and Vascular Disease;75
9.4;4. Mechanisms of Action of HRT in Vascular Biology;78
9.5;5. Effects of HRT on Inflammatory Markers;84
9.6;6. Conclusion;95
9.7;References;96
10;Chapter 4: Personalized Clinical Laboratory Diagnostics;108
10.1;1. Abstract;109
10.2;2. Introduction;109
10.3;3. Basic Concepts of Personalized Medicine;109
10.4;4. Molecular Diagnostic Technologies for Personalized Medicine;112
10.5;5. Role of PCR in Development of Personalized Medicine;112
10.6;6. Combined PCR-Enzyme-Linked Immunosorbent Assay (ELISA);115
10.7;7. Non-PCR Methods;116
10.8;8. Direct Molecular Analysis Without Amplification;116
10.9;9. SNP and Personalized Medicine;116
10.10;10. Genetic Variations in the Human Genome Other Than SNPs;118
10.11;11. Role of Biomarkers in Personalized Medicine;121
10.12;12. Application of Biochip Technology in Developing Personalized Medicine;122
10.13;13. Role of Nanobiotechnology-Based Diagnostics in Personalized Medicine;124
10.14;14. Role of Cytogenetics in Personalized Medicine;127
10.15;15. Integration of Molecular Diagnostics and Therapeutics;129
10.16;16. Concluding Remarks and Future Prospects;130
10.16.1;.;131
10.17;References;131
11;Chapter 5: Verification Of Method Performance For Clinical Laboratories;133
11.1;1. Abstract;133
11.2;2. Introduction;135
11.3;3. ISO Quality Management System: The Fundamentals of Quality;136
11.4;4. Laboratory Quality Standards in Regulations and Accreditation Guidelines;142
11.5;5. Comparison of Quality Requirements;144
11.6;6. Performing Method Verification;145
11.7;7. Summary;149
11.8;References;149
12;Chapter 6: Interpreting the Proteome and Peptidome in Transplantation;152
12.1;1. Abstract;153
12.2;2. Introduction;153
12.3;3. Application of Proteomics and Peptidomics in Transplantation;168
12.4;4. Important Issues;173
12.5;5. Conclusion;175
12.6;References;176
13;Chapter 7: Biomarkers in Long-Term Vegetarian Diets;184
13.1;1. Introduction;185
13.2;2. Possible Nutritional Deficiencies in Association with Long-Term Vegetarian Diets;186
13.3;3. Biomarkers of Oxidant/Antioxidant Balance in Association with Vegetarian Diets;199
13.4;4. Biomarkers that Reflect Lower Risk of Disease in Long-Term Vegetarians;207
13.5;5. Biomarkers to Differentiate the Vegetarian from the Nonvegetarian;220
13.6;6. Summary and Recommendations for Clinical Chemistry;222
13.7;References;223
14;Chapter 8: Effect of Caloric Restriction on Oxidative Markers;236
14.1;1. Abstract;237
14.2;2. Introduction;237
14.3;3. Foods and ROS Generation;238
14.4;4. Mitochondria as a Source of Reactive Oxygen and Nitrogen Species;239
14.5;5. Caloric Restriction and Oxidative Stress;242
14.6;6. Oxidative Stress Markers by Caloric Restriction;245
14.7;7. Data Interpretation;253
14.8;8. Conclusions;254
14.9;References;255
15;Index;262
16;Colorplate;274