Makowski Advances in Clinical Chemistry

1. Auflage 2009
ISBN: 978-0-08-095100-3
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 49, 200 Seiten

Reihe: Advances in Clinical Chemistry

Volume 49 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology. - Leading experts from academia and clinical laboratory science - Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Autoren/Hrsg.

Makowski, Gregory

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Clinical Chemistry;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Preface;12
7;Chapter 1: High-Sensitivity Troponin: A New Tool for Pathophysiological Investigation and Clinical Practice;14
7.1;2. Background and Aim;15
7.2;3. Introduction: Troponin Framework Within Myocardial Cells and Release Kinetics After Myocardial Damage;17
7.3;4. Impact of the New Definition of Myocardial Infarction on Laboratory Practice and Instrumentation: The Need for High-Sensitivity cTnI and cTnT Methods;18
7.4;5. The Impact of High-Sensitivity cTnI and cTnT Methods on Clinical Practice;22
7.5;6. High-Sensitivity cTnI and cTnT Methods: A Powerful Tool for Monitoring Physiological Renewal and Pathological Remodeling of the Myocardial Tissue?;32
7.6;7. Use of High-Sensitivity cTnI and cTnT Methods in a Multimarker Approach for Early Screening: An Increase in Diagnostic and Prognostic Efficiency?;35
7.7;8. Conclusion;36
7.8;References;37
8;Chapter 2: Biochemical Biomarkers of Oxidative Collagen Damage;44
8.1;2. The Collagen Family: Structure and Biochemistry;45
8.2;3. Chemical Nature and Reactivity of Oxygen;46
8.3;4. In Vivo Production of RNOS;48
8.4;5. RNOS Biological Activity;50
8.5;6. In Vivo Markers of Oxidant Stress;52
8.6;7. Oxidant-Induced Changes in Collagens;53
8.7;8. Biomarkers of Collagen Oxidative Damage;56
8.8;9. Critical Comments and Concluding Remarks;61
8.9;References;62
9;Chapter 3: Biochemical Basis of Fabry Disease with Emphasis on Mitochondrial Function and Protein Trafficking;70
9.1;2. Introduction;71
9.2;3. Inheritance;71
9.3;4. Clinical Picture;72
9.4;5. Diagnosis;72
9.5;6. Treatment;73
9.6;7. Biochemical Basis;75
9.7;References;81
10;Chapter 4: Urinary Biomarkers for the Detection of Renal Injury;86
10.1;2. Introduction;87
10.2;3. Biomarker Development for Kidney Diseases;88
10.3;4. Biomarkers for AKI;94
10.4;5. Biomarker Development and Implementation;103
10.5;6. Summary;104
10.6;References;105
11;Chapter 5: Biomarkers of Bone and Mineral Metabolism Following Bone Marrow Transplantation;112
11.1;2. Introduction;113
11.2;3. Clinical Features of BMT-Related Bone Loss;113
11.3;4. Changes in Bone-Turnover Markers After BMT;115
11.4;5. Calcium, Parathyroid Hormone (PTH), and Vitamin D;122
11.5;6. Sex Hormones;123
11.6;7. RANKL and Osteoprotegerin;125
11.7;8. Cytokines and Growth Factors;127
11.8;9. Conclusion;128
11.9;References;129
12;Chapter 6: Factor V Leiden and Activated Protein C Resistance;134
12.1;2. Introduction;135
12.2;3. The Protein C System;136
12.3;4. APC Resistance and FV Leiden;143
12.4;5. Conclusions and Perspectives;156
12.5;Acknowlegement;157
12.6;References;157
13;Chapter 7: Self-Assembled Tethered Bimolecular Lipid Membranes;172
13.1;2. Introduction;173
13.2;3. Assembly of tBLMs from Telechelics and Reconstitution of Proteins;175
13.3;4. The Peptide-Tethered Lipid Bilayer Membrane (peptBLM);178
13.4;5. Protein-Tethered Bilayer Lipid Membrane (protBLM);183
13.5;6. Conclusions;187
13.6;Acknowledgments;190
13.7;References;190
14;Index;194
15;Color Plates;200