Makowski Advances in Clinical Chemistry

1. Auflage 2011
ISBN: 978-0-12-387026-1
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 54, 204 Seiten

Reihe: Advances in Clinical Chemistry

Volumeÿ54 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. - Leading experts from academia and clinical laboratory science - Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Autoren/Hrsg.

Makowski, Gregory

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Clinical Chemistry;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Preface;12
7;Chapter 1: Heat-shock proteins in cardiovascular disease;14
7.1;Abbrevations;14
7.2;1. Abstract;16
7.3;2. Introduction;16
7.4;3. Atherogenesis and Possible Stimuli of Inducible HSPs;17
7.5;4. HSPs/Anti-HSPs as Biomarkers of Atherothrombosis;21
7.6;5. Molecular Mechanisms: Bystanders or Actors?;28
7.7;6. HSP as Therapeutic Targets in CVD/Atherothrombosis;38
7.8;7. Conclusions;41
7.9;Acknowledgments;41
7.10;References;42
8;Chapter 2: Polyamines in cancer;58
8.1;Abbrevations;58
8.2;1. Abstract;59
8.3;2. Introduction;59
8.4;3. Overview of Polyamine Regulation;60
8.5;4. Deregulation of Polyamines in Cancer;63
8.6;5. Genetic Variability in ODC Affecting Carcinogenesis;67
8.7;6. EIF5A and Cancer;69
8.8;7. Chemoprevention Strategies Within Polyamine Pathway;73
8.9;Acknowledgments;76
8.10;References;76
9;Chapter 3: Acquired hemophilia A;84
9.1;1. Abstract;84
9.2;2. Introduction;85
9.3;3. Pathogenesis;85
9.4;4. Laboratory Diagnosis;86
9.5;5. Conclusions;91
9.6;Acknowledgments;92
9.7;References;92
10;Chapter 4: Hypobetalipoproteinemia: Genetics, biochemistry, and clinical spectrum;94
10.1;Abbrevations;95
10.2;1. Abstract;95
10.3;2. Introduction;96
10.4;3. Pathways of apoB-Containing Lipoproteins Production;96
10.5;4. Dominant Forms of Primary HBL;100
10.6;5. Recessive Forms of Primary HBL;104
10.7;6. Primary Orphan FHBL;105
10.8;7. Spectrum of Clinical Manifestations in Primary HBL;105
10.9;8. Main Clinical Issues of FHBL;107
10.10;9. Secondary Hypobetalipoproteinemias;109
10.11;10. Conclusions;110
10.12;Addendum;112
10.13;Acknowledgment;114
10.14;References;114
11;Chapter 5: Sm peptides in differentiation of autoimmune diseases;122
11.1;1. Abstract;122
11.2;2. Introduction;123
11.3;3. Systemic Lupus Erythematosus;123
11.4;4. Mixed Connective Tissue Disease;125
11.5;5. Biochemical Aspects of the Sm Antigen;125
11.6;6. Characteristics of Anti-Sm Antibodies;126
11.7;7. Detection of Anti-Sm Antibodies;127
11.8;8. Clinical Association of Anti-Sm Antibodies;131
11.9;9. Meta-Analysis of Anti-Sm Antibodies;131
11.10;10. Genesis of Anti-Sm Antibodies;132
11.11;11. (Sm) Peptides as Antigens;132
11.12;12. Summary and Conclusion;135
11.13;13. Take Home Messages;135
11.14;References;135
12;Chapter 6: Aromatase activity and bone loss;142
12.1;1. Abstract;142
12.2;2. Introduction;143
12.3;3. Aromatase and Sources of Estrogen Production;144
12.4;4. The Aromatase Gene and Its Tissue-Specific Regulation;146
12.5;5. Aromatase Deficiency and the Bone;147
12.6;6. Skeletal Consequences of Aromatase Excess;158
12.7;7. Threshold Estradiol Hypothesis for Skeletal Sufficiency;159
12.8;8. Variability in the Level of Aromatase Activity: Effects on Bone Metabolism;161
12.9;9. Summary and Conclusions;166
12.10;References;167
13;Chapter 7: Biochemistry of adolescent idiopathic scoliosis;178
13.1;1. Abstract;179
13.2;2. Introduction;179
13.3;3. Bone Biochemical Parameters;181
13.4;4. Hormones;181
13.5;5. Trace Elements;184
13.6;6. Hematological Parameters-Platelets;184
13.7;7. Melatonin;185
13.8;8. Conclusions;191
13.9;References;192
14;Index;196