Manson Biomembranes

Erscheinungsjahr 2012
ISBN: 978-1-4684-7389-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 5, 284 Seiten, eBook

Reihe: Biomembranes

The volumes that have appeared in the three years since BIOMEMBRANES was launched illustrate the kinds of in formation the editor and the publishers envisaged would constitute the series. Some, such as this one, would consist of scholarly reviews of specialized topics; some, such as Volumes 2 and 3, would be the published chronicles of conferences; and others, such as Volumes 4 and 6, would be specialized monographs. In this way, we have hoped to provide not only reasoned critical opinions but also ideas "hot off the press. " Whether or not the views articulated ultimately stand the test of time is not as important as that their dissemination to the scientific community provides that unique stimulation that only flows from the interchange of ideas. This volumes includes chapters on a number of different topics. Rosenthal and Rosenstreich have reviewed the accumu lated evidence associating a visible structure of T lymphocytes, the Uropod, with immunologic "activation. " This is the first of many articles that will appear which associates the immune response with membrane function. A current example of Wallach's ability to approach a problem in a unique and original manner is contained in his review of the effects of ionizing radiation on membranes. Dale Oxender has been active in the study of transport for many years. His review is a careful documentary of the properties of specific binding proteins of bacteria and his thesis that these proteins are part of the active transport systems.

Zielgruppe

Research

Autoren/Hrsg.

Manson, Lionel A.

Inhaltsverzeichnis

1 The Lymphocyte Uropod: A Specialized Surface Site for Immunologic Recognition.- I. Introduction.- II. Classification of Lymphocytes.- III. Early Studies of Uropods on Mammalian Lymphocytes and Embryonic Cells.- IV. Uropods on Thymus-Derived or T Lymphocytes.- V. Morphologic Features of In Vivo and In Vitro Uropod-Bearing Lymphocytes.- VI. Absence of Uropods on Guinea Pig B Lymphocytes.- VII. Conclusion.- Acknowledgments.- References.- 2 Membrane Transport Proteins.- I. Introduction and Background.- II. Isolation of Components.- III. Binding Proteins from Bacteria.- IV. Chemotaxis and the Binding Proteins.- V. Role of the Binding Proteins in Transport.- VI. Summary.- References.- 3 The Membron: A Functional Hypothesis for the Translational Regulation of Genetic Expression.- I. Introduction.- II. Template Stability.- III. Kinetics of Template Stabilization.- IV. Intracellular Membranes and Translational Regulation of Genetic Expression.- V. The Membron: Hypothetical Structure and Function.- VI. Implications of the Membron Concept in the Regulation of Genetic Expression in Mammalian Systems.- Addendum.- Appendix I: Generation of Surfaces.- Appendix II: Conformational Membrane Changes.- References.- 4 Protein Synthesis by Membrane-Bound Polyribosomes.- I. Introduction.- II. Effects of Lipids and a Nonpolar Environment on Peptide Synthesis.- III. Effects of Lipophilic Agents on Protein Synthesis and Evidence for Initiation of Polyribosome Formation and Protein Synthesis on Membranes.- IV. A Review of the Evidence That Colicins Can Affect Protein Synthesis Without Entering the Cell.- V. Newer Evidence for the Presence of Amino Acids, Transfer RNA, Peptide Elongation Factors, Messenger RNA, and Ribosomes in Membranes.- VI. On the Possible Functions of Membrane-Bound Ribosomes.- Addendum.- Acknowledgments.- References.- 5 Radiation Effects on Biomembranes.- I. Introduction.- II. Radiation Chemistry of Membrane-Associated Substances.- III. Effects of Ionizing Radiation on Membrane Morphology.- IV. Radiation Effects on Membrane Function.- V. Membrane SH-Groups.- VI. Nuclear Membrane.- VII. Pleiotropic Effects.- Acknowledgments.- References.- 6 Protein Disposition in Biological Membranes.- I. Introduction.- II. The Lipid-Globular Protein Mosaic Model.- III. The Protein Crystal Model.- IV. Some Other Considerations.- V. Evidence for Proteins Which Penetrate and Span the Human Red Blood Cell.- VI. Conclusions.- Addendum.- Acknowledgments.- References.