Neuroglia in the Healthy Nervous System, Part I

Erscheinungsjahr 2025
ISBN: 978-0-443-19104-6
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 216 mm x 276 mm

Neuroglia in the Healthy Nervous System, Part I provides insights into newly emerging developments in neuroglia biology, focusing on the healthy nervous system. Driven by advances in genetics, transcriptomics, electrophysiological, and imaging techniques, this volume bridges the gap between neuroglia basic science and neuroglia clinical research. The book provides an overview of neuroglia biology, highlighting emerging technologies used to unravel the role of neuroglial cells in specific brain functions. The book also discusses strategies using neuroglia as a therapeutic target.

Autoren/Hrsg.

Weitere Mitwirkende

De Witte, Lotje D.

Aronica, Eleonora

Verkhratsky, Alexei

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

1. Neuroglia in the healthy brain: An introduction
2. Evolution of neuroglia: from worm to man
3. Orchestrating the glial compartment: ontogeny and developmental interaction of astrocytes, oligodendrocytes, and microglia
4. Glia and aging (rodent/human)
5. Physiology of neuroglia of the central nervous system
6. Gliotransmission in physiological and pathological conditions
7. Glia and brain energy metabolism
8. Neuroglia and the blood-brain barrier
9. Metabolic control of microglia in health and disease
10. The glymphatic system
11. Glia and brain-gut axis (rodent/human)
12. Glia and extracellular matrix molecules
13. In vitro models for human neuroglia
14. Animal-based approaches to understanding glia physiology in vitro and in vivo
15. Single-cell omics and heterogeneity of neuroglial cells
16. Imaging neuroglia

Über Autor(innen)

Aronica, Eleonora
Prof. E.M.A. Aronica is professor of Neuropathology at the University of Amsterdam's Faculty of Medicine (AMC-UvA).
Her research focuses on understanding the pathogenesis, epileptogenesis and pharmacoresistance of focal chronic pharmacoresistant epilepsy, as well as featuring translational aspects. The aim is to find an effective treatment for patients with epilepsy by mapping biological and molecular signalling pathways that contribute towards the development and progression of epilepsy and associated comorbidity. Aronica studies the control mechanisms of inflammatory processes, microRNAs, biomarkers to predict and diagnose the development of disease. Aronica focuses on neuropathological and applied research for patients with neurological diseases. She has published more than 300 peer-reviewed articles and several chapters for books.

De Witte, Lotje D.
Dr. de Witte is a psychiatrist with a background in preclinical research in the fields of virology and immunology. She is an MD PhD interested in how the immune system plays a role in psychotic disorders. In parallel to her residencies in psychiatry, she started her own research group at the Brain Center Rudolf Magnus in Utrecht, the Netherlands investigating the prevalence and role of neuronal auto-antibodies and neurotropic pathogens in psychotic disorders. He research has resulted in a novel and distinctive research line studying the phenotype and function of microglia in psychotic disorders.

Verkhratsky, Alexei
Professor Alexei Verkhratsky, PhD, DSc, is an internationally recognised scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia. He started glial research in 1989 in Heidelberg in the laboratory of Helmut Kettenmann. In a series of highly cited conceptual papers, he outlined basic principles of glial physiology and pathophysiology, which significantly influenced this rapidly developing area of neuroscience.