Newcombe Confidence Intervals for Proportions and Related Measures of Effect Size

Erscheinungsjahr 2012
ISBN: 978-1-4398-1279-2
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 468 Seiten

Reihe: Chapman & Hall/CRC Biostatistics Series

Confidence Intervals for Proportions and Related Measures of Effect Size illustrates the use of effect size measures and corresponding confidence intervals as more informative alternatives to the most basic and widely used significance tests. The book provides you with a deep understanding of what happens when these statistical methods are applied in situations far removed from the familiar Gaussian case.

Drawing on his extensive work as a statistician and professor at Cardiff University School of Medicine, the author brings together methods for calculating confidence intervals for proportions and several other important measures, including differences, ratios, and nonparametric effect size measures generalizing Mann-Whitney and Wilcoxon tests. He also explains three important approaches to obtaining intervals for related measures. Many examples illustrate the application of the methods in the health and social sciences. Requiring little computational skills, the book offers user-friendly Excel spreadsheets for download at www.crcpress.com, enabling you to easily apply the methods to your own empirical data.

Zielgruppe

Researchers, students, and applied statisticians involved in quantitative research in the health and social sciences.

Autoren/Hrsg.

Newcombe, Robert G.

Newcombe, Robert Gordon

Fachgebiete

• Sozialwissenschaften Soziologie | Soziale Arbeit Soziologie Allgemein Empirische Sozialforschung, Statistik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik

Inhaltsverzeichnis

Hypothesis Tests and Confidence Intervals
Sample and Population
Hypothesis Testing and Confidence Intervals: The Fundamentals
Why Confidence Intervals Are Generally More Informative Than p-Values
Measures of Effect Size
When Are Point and Interval Estimates Less Helpful?
Frequentist, Bayesian and Likelihood Intervals
Just What Is Meant by the Population?
The Unit of Data
Sample Size Planning

Means and Their Differences
Confidence Interval for a Mean
Confidence Interval for the Difference between Means of Independent Samples
Confidence Interval for the Difference between Two Means Based on Individually Paired Samples
Scale Transformation
Non-Parametric Methods
The Effect of Dichotomising Continuous Variables

Confidence Intervals for a Simple Binomial Proportion
Introduction
The Wald Interval
Boundary Anomalies
Alternative Intervals
Algebraic Definitions for Several Confidence Intervals for the Binomial Proportion
Implementation of Wilson Score Interval in MS Excel
Sample Size for Estimating a Proportion

Criteria for Optimality
How Can We Say Which Methods Are Good Ones?
Coverage
Expected Width
Interval Location
Computational Ease and Transparency

Evaluation of Performance of Confidence Interval Methods
Introduction
An Example of Evaluation
Approaches Used in Evaluations for the Binomial Proportion
The Need for Illustrative Examples

Intervals for the Poisson Parameter and the Substitution Approach
The Poisson Distribution and Its Applications
Confidence Intervals for the Poisson Parameter and Related Quantities
Widening the Applicability of Confidence Interval Methods: The Substitution Approach

Difference between Independent Proportions and the Square-and-Add Approach
The Ordinary 2 x 2 Table for Unpaired Data
The Wald Interval
The Square-and-Add or MOVER Approach
Other Well-Behaved Intervals for the Difference between Independent Proportions
Evaluation of Performance
Number Needed to Treat
Bayesian Intervals
Interpreting Overlapping Intervals
Sample Size Planning

Difference between Proportions Based on Individually Paired Data
The 2 x 2 Table for Paired Binary Data
Wald and Conditional Intervals
Intervals Based on Profile Likelihoods
Score-Based Intervals
Evaluation of Performance

Methods for Triads of Proportions
Introduction
Trinomial Variables on Equally Spaced Scales
Unordered Trinomial Data: Generalising the Tail-Based p-Value to Characterise Conformity to Prescribed Norms
A Ternary Plot for Unordered Trinomial Data

Relative Risk and Rate Ratio
A Ratio of Independent Proportions
Three Effect Size Measures Comparing Proportions
Ratio Measures Behave Best on a Log Scale
Intervals Corresponding to the Empirical Estimate
Infinite Bias in Ratio Estimates
Intervals Based on Mesially Shrunk Estimated Risks
A Ratio of Proportions Based on Paired Data
A Ratio of Sizes of Overlapping Groups
A Ratio of Two Rates
Implementation in MS Excel

The Odds Ratio and Logistic Regression
The Rationale for the Odds Ratio
Disadvantages of the Odds Ratio
Intervals Corresponding to the Empirical Estimate
Deterministic Bootstrap Intervals Based on Median Unbiased Estimates
Logistic Regression
An Odds Ratio Based on Paired Data
Implementation

Screening and Diagnostic Tests
Background
Sensitivity and Specificity
Positive and Negative Predictive Values
Trade-Off between Sensitivity and Specificity: The ROC Curve
Simultaneous Comparison of Sensitivity and Specificity between Two Tests

Widening the Applicability of Confidence Interval Methods: The Propagating Imprecision Approach
Background
The Origin of the PropImp Approach
The PropImp Method Defined
PropImp and MOVER Wilson Intervals for Measures Comparing Two Proportions
Implementation of the PropImp Method
Evaluation
The T

Über Autor(innen)

Robert G. Newcombe is a professor in the Institute of Primary Care and Public Health at Cardiff University School of Medicine, where he teaches medical statistics and epidemiology and is involved in medical and dental research. Dr. Newcombe is a member of the editorial board of Statistical Methods in Medical Research and serves on the Cardiff & Vale Research Review Service and Wales Ambulance Service Trust Research & Development panels.