Epigenetic Therapy by Phytochemicals in Lung Cancer

Mechanisms, Therapeutic Potential, and Clinical Implications
Erscheinungsjahr 2026
ISBN: 978-0-443-45146-1
Verlag: Elsevier Science

Buch, Englisch, 600 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Epigenetic Therapy by Phytochemicals in Lung Cancer provides a comprehensive exploration of the intersection between cancer epigenetics and phytotherapy, focusing on lung cancer. The book emphasizes the role of epigenetic alterations in cancer progression and presents phytochemicals as promising agents capable of reversing these changes, thereby offering innovative therapeutic strategies. The content examines the mechanisms by which epigenetic modifications, such as DNA methylation and histone modification, contribute to lung cancer. It details specific phytochemicals-like curcumin, resveratrol, and quercetin-and their potential to modulate these pathways, while discussing clinical applications, challenges, and future research directions. For academics, this book equips researchers and healthcare professionals with evidence-based insights into alternative cancer therapies, enhancing understanding of multi-targeted approaches. It serves as a valuable reference for teaching and further research, promoting a more inclusive perspective in cancer care and addressing disparities in treatment access and efficacy.

Autoren/Hrsg.

Parashar, Deepak

Singh, Sandeep Kumar

Kumar, Umesh

Kumar, Sachin

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Section I: Introduction to Lung Cancer and Epigenetics
1. Lung Cancer: Epidemiology, Pathophysiology, and Current Therapies
2. The Role of Epigenetic Alterations in Lung Cancer Progression
3. Epigenetic Therapy: Overview and Emerging Frontiers

Section II: Phytochemicals as Epigenetic Modulators
4. Introduction to Phytochemicals with Epigenetic Activity
5. DNA Methylation Modulation by Phytochemicals
6. Histone Modification Regulation by Plant-based Compounds
7. Impact of Phytochemicals on Non-coding RNAs in Lung Cancer

Section III: Phytochemicals in Lung Cancer Therapy - Mechanisms and Evidence
8. Polyphenols as Epigenetic Modulators: Curcumin, Resveratrol, and Quercetin
9. Flavonoids and Epigenetic Therapy in Lung Cancer
10. Terpenoids and Their Role in Lung Cancer Epigenetic Modulation
11. Alkaloids and Lung Cancer Epigenetics: Mechanistic Insights and Case Studies

Section IV: Clinical Implications and Future Directions
12. Preclinical and Clinical Trials of Phytochemicals in Lung Cancer Epigenetics:.
13. Insights into clinical trials and real-world applications of phytochemicals
14. Challenges in Phytochemical-based Epigenetic Therapy
15. Formulation and Delivery Systems for Phytochemical-based Epigenetic Drugs
16. Combination Therapies: Phytochemicals with Conventional Lung Cancer Therapies
17. Conclusion and Future Perspectives in Epigenetic Phytotherapy for Lung Cancer
18. Cancer immunotherapy, including CAR-T cell therapy and immune checkpoint inhibitors

Über Autor(innen)

Kumar, Sachin
Dr. Sachin Kumar is a Scientist and Head of Division in the Biochemical Conversion Division at the Sardar Swaran Singh National Institute of Bio-Energy, Kapurthala, India. He was a Visiting Professor in the Department of Chemical and Biological Engineering at South Dakota School of Mines and Technology, USA, for a year, and obtained his Ph.D. in Chemical Engineering from the Indian Institute of Technology, Roorkee, India. With more than twenty years of research experience in biochemical conversion of biomass to biofuels, Dr. Kumar has published over 85 papers in peer reviewed journals, book chapters and papers in conference proceedings, as well as 9 edited books. He has one granted US patent and one Indian patent, and four filed Indian patents. He has delivered 80 invited/plenary lectures and presented 75 papers at national and international conferences. He received the 2016 ASM-IUSSTF Indo-US Research Professorship and was selected as the Bioenergy-Awards for Cutting Edge Research (B-ACER) Fellow 2016 by DBT and IUSSTF.

Singh, Sandeep Kumar
Assistant Professor in Department of Medical Biotechnology at the All India Institute of Medical Sciences, Nagpur. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. His research interests are in neurodegenerative diseases and has ~12 years of experience. He's a member of editorial boards of several international journals related to neuroscience and member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad.

Parashar, Deepak
Dr. Deepak Parashar earned his PhD in 2016 from the National Institute of Immunology and Jaipur National University, focusing on the role of SOX4 in cervical cancer. He then joined Dr. Chaluvally's lab as a postdoctoral fellow at the Medical College of Wisconsin, where he investigated microRNAs like miR551b in breast and ovarian cancers and screened anti-cancer drugs for ovarian treatment. In 2022, he became an Assistant Professor in Dr. Janz's lab, researching immuno-oncology in multiple myeloma (MM). His current work explores microRNAs and transcription factors like FOXM1 in the tumor immune microenvironment to enhance immunotherapies. Additionally, he studies drug resistance mechanisms and develops nanotechnology-based targeted drug delivery systems for preclinical models. Dr. Parashar has published over 50 manuscripts in prestigious journals and has over 10 years of cancer research experience, mentoring postdocs and graduate students while serving as a peer reviewer and associate editor for various journals.

Kumar, Umesh
Dr. Umesh Kumar is a Professor in the Department of Biosciences at IMS Ghaziabad (University Courses Campus) and has led the Research Department since 2019. Previously, he served as a Scientific Officer in the Department of Biochemistry at the University of Delhi. He earned his Ph.D. in Biomedical Sciences, focusing on "Epigenetic Regulation in Breast Carcinogenesis," from the Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, in 2013. Dr. Kumar's research interests include molecular diagnosis of cervical cancer, molecular epigenetics of breast carcinogenesis, CAR T-cell therapy, and tumor virology. He has published 50 research articles and contributed over 21 book chapters to reputable publishers. He has received multiple grants and has been honored with two Young Scientist Awards and one Senior Scientist Award. Additionally, he reviews for several international journals and serves as a Doctoral Research Committee (DRC) Expert member at various Indian universities.