Biomarkers in Kidney Transplantation

Clinical Aspects and Laboratory Determinations
Erscheinungsjahr 2025
ISBN: 978-0-12-824069-4
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 308 Seiten, Format (B × H): 214 mm x 275 mm, Gewicht: 1000 g

Reihe: Clinical Aspects and Laboratory Determination

Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.

Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.

Zielgruppe

<p>Primary: Pathologists, clinical pharmacologists and clinical laboratory scientists, physicians involved in organ transplantation, immunologists and transplant surgeons, etc.</p> <p>Secondary: Nurse practitioners and clinical pharmacists working in organ transplant divisions; and scientists working in diagnostic industries to develop commercially viable assays for new transplant biomarkers.</p>

Autoren/Hrsg.

Pattanaik, Dr Smita

Sharma, Dr Ashish

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Organ transplantation: past, present, and future
2. Trends in kidney transplantation
3. Immunobiology in kidney transplantation
4. Immunosuppression in kidney transplantation
5. Challenges in the therapeutic drug monitoring of immunosuppressants
6. Overview of biomarkers in kidney transplantation
7. Biomarkers for ischemia reperfusion injury and delayed graft function
8. Biomarkers of renal transplant rejection: yesterday, today, and tomorrow
9. Biomarkers predicting the response to immunosuppressant therapy
10. Biomarkers of recurrent disease after kidney transplantation
11. Biomarkers of tolerance in renal transplantation
12. Biomarkers for detecting opportunistic infections in renal transplant recipients
13. Biomarkers for detecting nephrotoxicity due to immunosuppressant drugs
14. Biomarkers for drug development in kidney transplantation
15. Commercially available biomarker tests in kidney transplantation
16. The unmet needs, current challenges and future directions for biomarkers in renal transplantation

Über Autor(innen)

Pattanaik, Dr Smita
Dr. Smita Pattanaik is a physician-scientist involved in teaching postgraduate students of clinical pharmacology and clinical patient care services, focusing on the delivery of precision medicine in clinics through therapeutic drug monitoring, pharmacogenomics, and model-informed precision dosing. Her research group, the Translational Pharmacology Laboratory, comprises clinicians, clinical scientists, and basic scientists. The goal is bedside-to-bench and bench-to-bedside translation involving immunosuppressant drugs (ISDs), the repositioning of drugs as anticancer agents, and collaborative clinical trials. Most of the current projects focus on organ transplantation, autoimmune diseases, and cancer.

Sharma, Dr Ashish
Ashish Sharma is a highly experienced transplant surgeon. He has more than 200 publications in national and international journals. He has been instrumental in starting academic training programs in kidney and pancreas transplant at PGIMER. Under his leadership, the department has been able to establish a pancreas transplant program, donation after cardiac death, along with a comprehensive surveillance and interventional vascular access program. He has been awarded by the Ministry of Health and the Indian Society of Organ Transplant for his exemplary services in transplant.