Permyakov / Kretsinger Calcium Binding Proteins

1. Auflage 2011
ISBN: 978-0-470-87238-3
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 592 Seiten, E-Book

Reihe: Wiley Series in Protein and Peptide Science

Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.

Autoren/Hrsg.

Permyakov, Eugene

Kretsinger, Robert H.

Inhaltsverzeichnis

Preface.
1. Historical Perspective.
2. Physiological Processes Involving Calcium BindingProteins.
3. Comparison of the Ca¯2+ Ion with Other MetalCations.
4. Complexes of Calcium and Other Cations with Low MolecularWeight.
5. Stoichiometry, Kinetics, and Thermodynamics of CalciumBinding.
6. Experimental Methods Used to Study Calcium Binding toProteins.
7. Structure and Evolution of Proteins.
8. Protein Complexes with Metals Other than Calcium.
9. Nonessential Metals.
10. Parvalbumin.
11. EF-Hand Proteins.
12. Cytosolic Calcium Binding Proteins Lacking EF-Hands.
13. Extracellular Calcium Binding Proteins.
14. Interactions of Calcium Binding Proteins with Other MetalIons.
15. Interactions of Calcium Binding Proteins with Other Proteinsand with Membranes.
16. Genetic Engineering of Calcium Binding Proteins.
References.
Index.

Über Autor(innen)

Eugene A. Permyakov received his PhD in physics andmathematics at the Moscow Institute of Physics and Technology in1976 and defended his Doctor of Science dissertation in biology atMoscow State University in 1989. From 1970 to 1994, he worked atthe Institute of Theoretical and Experimental Bio-physics of theRussian Academy of Sciences. Since 1994 he has been the Director ofthe Institute for Biological Instrumentation of the Russian Academyof Sciences. He is known for his work on metal binding proteins andthe intrinsic fluorescence method. His primary research focus isthe study of physico-chemical and functional properties of metalbinding (especially calcium-binding) proteins.
Robert H. Kretsinger received his PhD in biophysics atthe Massachusetts Institute of Technology under the supervision ofAlex Rich in 1964. In 1967 he set up a protein crystallography labin the Department of Biology at the University of Virginia, wherehe¿presently teaches, and determined the crystal structure ofparvalbumin as well as describing the EF-hand domain in 1971. Hehas subsequently investigated the structures, functions, andevolution of various EF-hand homologs, along with other proteinfamilies. From 1978 to 1995, he directed a national facility tobuild multiwire area detectors for x-ray diffraction and to collectdata from protein crystals.