Mosaic of Autoimmunity

The Novel Factors of Autoimmune Diseases
Erscheinungsjahr 2019
ISBN: 978-0-12-814307-0
Verlag: Elsevier Science

Buch, Englisch, 728 Seiten, Format (B × H): 278 mm x 219 mm, Gewicht: 1970 g

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.

An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

Zielgruppe

Researchers and physicians in immunology, autoimmune diseases, genetics, virologists and molecular biologists. Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, rheumatology, genetics, cell biology and molecular and microbiology

Autoren/Hrsg.

Perricone, Carlo

Shoenfeld, Yehuda

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

Introduction 1. The history of the mosaic of autoimmunity 2. The novel aspects on the mosaic of autoimmunity?

Cellular and molecular mechanisms 3. B cells 4. B-reg? 5. T cells 6. Th17 cells 7. NK cells 8. Dendritic cells 9. Complement 10. Autoantibodies 11. Anti-DSF70 12. Genetic 13. Epigenetic 14. Post-translational modifications 15. Cytokines and chemokines 16. Autophagy 17. Diagnostic: laboratory? 18. Diagnostic: imaging

The classical factors associated with autoimmunity 19. Hormones 20. Microbiota 21. Infections: Viruses and bacteria

The novel environmental factors associated with autoimmunity 22. Geo-epidemiology 23. Seasonality 24. UV 25. Vitamin D 26. Vitamin D pregnancy and autoimmunity 27. Smell 28. Breast feeding 29. Vaccines 30. Silicone 31. Diet: spicy food and fatty acids 32. Diet: gluten 33. Psychological stress 34. Coffee 35. Obesity 36. Physical activity 37. Smoke 38. Cannabis 39. Bisphenol 40. Prolactin

Peculiar aspects 41. Cancer 42. Paraneoplastic syndromes

Classical autoimmune diseases 43. SLE 44. APS 45. CAPS 46. RA and inflammatory arthritides 47. PsA and Spondyloarthropathies 48. MS, MG and other neurological disorders 49. Systemic slcerosis 50. Sjogren 51. ASIA syndrome 52. Reproductive failure 53. Accelerated atherosclerosis 54. New autoimmune diseases

Treatment of autoimmune diseases 55. Neuroimmunology 56. Vasculitis 57. Personalized Medicine 58. Biologics and Biosimilars 59. Small molecules 60. Helminthes 61. Novel therapies and IVIg 62. Autoimmune and allergic disease 63. EBV Molecular Diagnosis 64. Statin and myositis 65. Autoimmunity and primary immunodeficiency

Über Autor(innen)

Shoenfeld, Yehuda
Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002-Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Perricone, Carlo
Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome