Pinna Protein Kinase CK2

1. Auflage 2012
ISBN: 978-1-118-48238-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 480 Seiten, E-Book

Reihe: The Wiley - IUBMB Series on Biochemistry and Molecular Biology

Protein kinases play a critical role in cellular processes thatimpact overall organismal health and function. Of the kinases thatcollectively make up the Human Kinome, CK2 has garnered specialattention because of its significant role in the generation of thehuman phosphoproteome. The role CK2 plays in the development ofcancer and other disease has also made it of significant interestfor its potential role in future therapeutics. Protein KinaseCK2 comprehensively brings together the varied work being doneon this critical enzyme.
Protein Kinase CK2 is logically divided into threesections. The first section reviews key molecular and structuralaspects of the enzyme. The second section looks at functionalaspects of CK2 and the diverse roles it plays in cellulardevelopment, function, and health. The final section focuses on CK2and cancer, looking at the impacts of the kinase on neoplasticdevelopment and its rapidly developing role as a therapeuticagent.
With contributions from the world's leading experts in thefield, Protein Kinase CK2 will serve as an invaluable guideto the expanding and vibrant body of research being performed onthis enzyme. This will be an essential volume for anyone working inthe fields of biochemistry, protein science, signal transduction,metabolic regulation, and cancer biology and therapeutics.
Editor
Lorenzo A. Pinna is Professor in the Department ofBiomedical Sciences at the University of Padua, Padua, Italy.
Also Published in the Wiley-IUBMB Series on Biochemistry andMolecular Biology:
Plant Phenolics and Human Health: Biochemistry, Nutrition,and Pharmacology
Edited by Cesar G. Fraga
ISBN: 978-0-470-28721-7

Autoren/Hrsg.

Pinna, Lorenzo A.

Inhaltsverzeichnis

PART I: INTRODUCTION
1. "CK2, a protein kinase for all seasons" (Lorenzo A. Pinna Dept. Biological Chemistry, University of Padua, Padua, Italy.
PART II: MOLECULAR AND STRUCTURAL ASPECTS
2. "CK2 structures in the light of the spine concept of eukaryotic protein kinases " (Karsten Niefind, University of Cologne, Institute of Biochemistry, Cologne, Germany. E
3. "Structural bases for CK2 inhibition" (Roberto Battistutta, Department of Chemistry, University of Padua- Padova, Italy.
4. "The interactome of protein kinase CK2" (Mathias Montenarth, University of the Saarland, Medical Biochemistry and Molecular Biology, Homburg, Germany.
5. "The phosphoproteome generated by protein kinase CK2" (Mauro Salvi & Lorenzo A. Pinna Dept. Biological Chemistry, University of Padua, Padua, Italy.
PART III: FUNCTIONAL ASPECTS
6. "Intersection of CK2 with other signalling pathways" (David Litchfield, University of Western Ontario, Department of Biochemistry, London, Ontario, Canada.
7. "The role of protein kinase CK2 in the p53 response" (David W. Meek, University of Dundee, Biomedical Research Institute Ninewells Hospital, Dundee, UK.
8. "CK2 in embryonic development" (Isabel Dominguez, Boston University School of Medicine, Boston, MA, USA.
9. "Role of CK2 in the control of epithelial cell plasticity" (Claude Cochet, INSERM U873 iRTSV- CEA Grenoble, France.
10. "CK2 and circadian rhythm"
11. "The pivotal role of CK2 in chaperoning the kinome" (Yoshihiko Miyata, Kyoto University, Dept. Cell & Develop. Biology, Kyoto, Japan.
12. "CK2: a global regulator of cell survival" (Olaf-G. Issinger, University of Southern Denmark, Institute of Biochemistry and Molecular Biology, Odense, Denmark.
13. "Specific features of plant CK2" (Montserrat Pages, CSIC, CRAG, Barcelona, Spain.
PART IV: CK2 AND NEOPLASIA
14. "The oncogenic potential of CK2" (David C. Seldin, Boston University Medical Center, Department of Medicine, Boston MA, USA.
15. "CK2 suppression of apoptosis and its implication in cancer biology and therapy" (Khalil Ahmed, University of Minnesota and V.A. Medical Center, Minneapolis, MN, USA.
16. "Abnormal levels of CK2 and the generation of cancer "addiction" (Maria Ruzzene, Dept. Biological Chemistry, University of Padua, Padua, Italy.
17. "CK2 as an ideal target in cancer therapy: combining inhibitors of CK2 with various classes of chemotherapeutic agents" (Kenna Anderes, Cylene Pharmaceuticals, Cancer Biology, San Diego, CA, USA.
18. " CK2 in normal and malignant hematopoiesis" (Francesco Piazza, Venetian Institute of Molecular Medicine - VIMM, Padova, Italy.