Comprehensive Handbook of Alcohol Related Pathology

Special Auflage
ISBN: 978-0-12-564370-2
Verlag: Elsevier Science

Buch, Englisch, 2192 Seiten, Format (B × H): 216 mm x 286 mm, Gewicht: 5525 g

This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.

Zielgruppe

Researchers involved in the field of alcohol-related harm, institutions, libraries, PhD students, clinicians and pathologists.

Autoren/Hrsg.

Preedy, Victor R

Watson, Ronald Ross

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tierphysiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik

Inhaltsverzeichnis

Contributors
Preface

Foreword

Volume One
Part I: General Aspects of Alcohol Toxicity, Consumption, and Disease
Evolutionary and Historical Aspects of Ethanol Ingestion
Alcohol Metabolism: General Aspects

Intake of Different Alcoholic Beverages and Life-style and Psychosocial Factors

Genetic Aspects of Alcohol Metabolism: An Overview

Predictors of Alcohol Consumption

Binge Drinking: Patterns, Explanations, and Policy

Breath and Blood Alcohol

Effects of Food and Body Composition on Blood Alcohol Levels

Disposal of Ethanol Carbon Atoms

Effect of Alcohol on Water and Sodium Homeostasis

Energy from Alcohol

The Mediterranean Diet and the Contribution and Role of Alcohol

The Role of Alcohol in Injury Deaths

Death from Alcohol Poisoning

Alcohol and the Workplace
Alcohol Misuse in Adolescents: Epidemiology, Clinical Characteristics,
Diagnosis, and Treatment

Alcohol Misuse in Adolescents: Individual Differences, Prevention,
Identification, and Intervention

What is the Impact of Alcohol on Learning in University Students?
The Relationship Between Alcohol Misuse and the Homelessness

Alcohol and Sport Activities: Spectator's Perspective
Part II: Damage/Disease
General Aspects of Pathology
An Overview of Pathologies Occurring in Alcohol Abusers

Gender Differences in Alcohol Pathology

Psychological Effects of Alcohol Misuse

The Effect of Alcohol on Quality of Life

Alcohol and Road Accidents

Trauma and Alcohol

Clinical Implications of Alcohol Misuse for Surgery

Fetal Alcohol Spectrum Disorder

Nutritional Status in Alcoholics

Alcohol and Body Composition

Beneficial Components of White Wine

Polyphenols and Alcohol: Complementary Mechanisms for the Protective
Effects of Moderate Wine Consumption

Overview of ALDH Polymorphism: Relation to Cardiovascular Effects of Alcohol

Overview on the Effects of Amount and Type of Alcohol on Morbidity and Mortality

Alcohol-related Mortality in Russia

(ii) Organ Damage

Epidemiology and Risk Factors Involved in Alcoholic Liver Disease

Polymorphism and Alcoholic Liver Disease

Liver Injury During Alcohol Use and Withdrawal

Alcohol Consumption and Diabetes Mellitus

Alcoholic Ketoacidosis

Alcohol, Alcoholism and Effects on the Kidney and Kidney Disease

Alcohol Intake and the Lower Urinary Tract

Alcohol and Prostate Cancer

Oral Health and Alcohol

Volume 2
Alcohol and the Gastrointestinal Tract

Alcohol, ALDH2 Genotypes and Intestinal Cancer

Alcohol and Pancreatitis
The Skin and Alcohol

Alcohol, Blood Pressure and Hypertension

Alcohol and Stroke

Alcoholic Cardiomyopathy

Epidemiologic Aspects of ALDH2 Genotypes and Cardiovascular Parameters
Alcoholic Myopathy: Clinical Aspects

Alcohol and the Eye: Friend or Foe

Marchiafava-Bignami Disease in Alcoholism

Peripheral Neuropathy

(iii) Cells, Pathways, Interactions, Processes

Defects in Methionine Metabolism: Its Role in Ethanol-induced Liver Injury

Roles of Kupffer Cells in Alcoholic Liver Disease

The Role of the Stellate Cell in Alcohol Mediated Tissue Injury

The Role of T Lymphocytes in the Pathogenesis of Alcoholic Liver Disease

Oxidative Stress in Alcoholic Liver Disease: Clinical Studies

The Relationship between Alcohol-induced Apoptosis and Oxidative Stress in the Liver

Alcohol and HIV Interactions in the Natural History and Treatment of HIV/AIDS

Alcohol and Hepatitis Virus Interactions in Liver Pathology

Moderate Alcohol and Fibrosis in Chronic Viral Hepatitis

Ethanol-Taurine Interactions in the Brain: Mechanisms and
Pathophysiological Implications
The Effect of Ethanol on Ion Channels in the Brain: A New Look
A Nitric Oxide Signaling Pathway Protects the Developing Brain against
Alcohol-induced Neuronal Death

Signaling Pathways in the Heart and Moderate Alcohol Intake

Effects of Alcohol on Vascular Function

Vascular and Biochemical Effects of Moderate Alcohol Consumption:

Mechanisms of Protection Against Cardiovascular Disease

Alcohol and Xenobiotics in Placenta Damage

Molecular Mechanisms in Fetal Alcohol Syndrome: Shh-signaling
The Process of Bacterial Translocation and Implications for Health in Alcoholics

Alcohol, Altered Gut Permeability, and Endotoxins

Hormonal Responses in Alcoholism

Alcohol-induced Changes in the GH-IGF Axis

Mechanisms in Prostate Damage by Alcohol

Signaling Pathways in Human Breast Cells in Response to Alcohol:

Mechanisms for Alcohol-induced Breast Cancer

The Ubiquitin-Proteasome System in Alcohol-Induced Pathology

Alcohol and Alkylating Agents

DNA Damage Resulting from Alcohol Abuse with Special Reference to the Brain

Purine Metabolism and the Influence of Alcoholic Beverages

The Role of PKC Isozymes in Mediating Responses to Ethanol

Ethanol Modulation of cAMP-dependent Protein Kinase Subunits Activity:

Mechanisms and Functional Consequences

Adhesion Molecules and Alcohol Consumption

Glucose-regulated Stress Proteins (GRPs) and Alcohol

Heat Shock Proteins and Alcohol

Role of Oxidative Stress in Alcohol-Induced Mitochondrial Dysfunction

Alcohol and Apoptosis

Volume 3
Alcohol and Fatty Acid Ethyl Esters

Modification of Proteins by Reactive Ethanol Metabolites: Adduct Structure, Functional and Pathological Consequences

The Effect of Acetaldehyde on Plasma

Autoantibodies in Alcohol-related Tissue Diseases

Alcohol-induced Membrane Damage

Alcohol Abuse and Eating Disorders

The Relationship Between Obesity and Alcoholic Pathology

Protein Deficiency and Alcohol: Interactions and Organ Effects

Tryptophan Metabolism and Alcoholism

Part III: Selective Methods Used in Alcohol Research

Selective Methods Used in Alcohol Research: Screening in Primary Care - Methods
and Approaches

Psychometric Assessment of Alcohol Use

Self-reported Intake of Alcohol: Methods and Approaches
Use of the DSM-IV: Methods and Approaches

The Alcohol-related Problems Survey: Developing and
Testing a Screening Measure for Older Adults

The Rapid Alcohol Problems Screen: Methods and Application

Methods for Determining Blood Alcohol Concentration: Current and
Retrospective

Urinary Markers of Alcohol Consumption

Methods for Measuring Genetic Variations in ADH
and SLDH Loci: A Practical Approach

Histological Localization of Alcohol Dehydrogenase: Methods, Approaches and Applications

Assays for Alcohol and Aldehyde Dehydrogenase: Methods, Approaches and Applications

Detecting ADH and ALDH Enzymes in Cells and Tissues using Western Blotting

Use of Selectively Bred Alcohol-preferring Rats to Study Alcohol
Abuse, Relapse and Craving

Animal Models of Chronic Alcohol-Induced Liver Damage

Acute Ethanol Dosing Regimens: Methods and Approaches

Use of Isolated Cells in the Study of Ethanol-Induced Hepatotoxicity

Animal Models of Fetal Alcohol Syndrome: Methods and Approaches

Genetically Engineered Animals in Alcohol Research

cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches

Practical Methods for Determining mRNA Levels in Alcohol-Exposed
Tissues and Its Application to Experimental Pathology

Diagnosis of Fetal Alcohol Syndrome: Measurement of the Facial Dysmorphology

Nuclear Magnetic Resonance: Methods and Application to Alcohol Effects in the Liver

Index

Über Autor(innen)

Watson, Ronald Ross
Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watson's career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models.

Preedy, Victor R
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King's College Hospital and Emeritus Professor of Nutritional Biochemistry at King's College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King's College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Edited by Victor R. Preedy and Ronald Watson