Rahman / Choudhary Drug Design and Discovery in Alzheimer's Disease

1. Auflage 2015
ISBN: 978-0-12-803960-1
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 784 Seiten

Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of á-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. - Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development - Describes existing drugs for AD and current molecular understanding of the condition - Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Autoren/Hrsg.

Rahman, Atta-Ur

Choudhary, Muhammad Iqbal

Leseproben

List of Contributors
A. Michael Crider     United Arab Emirates University, Faculty of Medicine and Health Sciences, Department Pharmacology and Therapeutics, Al Ain, UAE Abdu Adem     Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE Adel M. Abuzenadah     King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia Ali Jawad     Department of Applied Physics, Zakir Husain College of Engineering and Technology, Aligarh Muslim University, Aligarh UP, India Benjamin P. Repsold     Pharmaceutical Chemistry, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa Boris Decourt     Banner Sun Health Research Institute, Sun City, AZ, USA Carmen Martínez-Rincón     Nursing Department, Complutense University of Madrid, Spain Daniel Jun     University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic Darrick Pope     Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, USA David F. Fischer     BioFocus; Leiden, The Netherlands David William Klaver     Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA Dolores Rodríguez-Martínez     Nursing Department, Complutense University of Madrid, Spain Eric A. Owens     Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303, USA Eugenie Nepovimova     Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic Faizul H. Nasim     Department of Chemistry, BJ Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan Fares Zeidán-Chuliá     Center of Oxidative Stress Research, Department of Biochemistry, Postgraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil Farhan Jalees Ahmad     Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India Farzana L. Ansari     Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan Filip Zemek     Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic Giuseppina Tesco     Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA Gjumrakch Aliev     Department of Health Science and Healthcare Administration, University of Atlanta, Atlanta, GA, USA, and GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA Iqbal Ahmad     Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India Ismael Ortuño-Soriano     Institute for Health Research at the San Carlos Clinical Hospital (IdISSC), Madrid, Spain; Nursing Department, Complutense University of Madrid, Spain Jacobus P. Petzer     Pharmaceutical Chemistry, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa Jacques Joubert     School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa Jan Korabecny     Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic Javed Ahmad     Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India José Cláudio Fonseca Moreira     Center of Oxidative Stress Research, Department of Biochemistry, Postgraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil José L. Pacheco-del-Cerro     Nursing Department, Complutense University of Madrid, Spain Julie Frearson     BioFocus; Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, UK Kamil Kuca     University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic Kamil Musilek     University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic Karin E. Sandoval     Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, USA Katarina Spilovska     Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic Kenneth A. Witt     Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, USA Lara Pacheco-Cuevas     Nursing Department, Complutense University of Madrid, Spain Louis H.A. Prins     Department of Pharmacy, University of Namibia, Windhoek, Namibia Maged M. Henary     Department of Chemistry, Center for Diagnostics and Therapeutics, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia, 30303, USA Maria Kontoyianni     Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, USA Marwan Sabbagh     Banner Sun Health Research Institute, Sun City, AZ, USA Mauricio Alcolea-Palafox     Chemical-Physics Department, Chemistry Faculty, Complutense University of Madrid, Spain Michael Cascio     Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, USA Michael D. Wall     BioFocus; Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, UK MiMi Macias     Banner Sun Health Research Institute, Sun City, AZ, USA Mohamed A. Embaby     Department of Chemistry, Faculty of Sciences & Arts Khulais, King Abdulaziz University, Jeddah, KSA Mohammad A. Kamal     King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia Mohammad Zaki Ahmad     Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia Nasimudeen R. Jabir     King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia Nigel H. Grieg     Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA Nighat Sultana     Pharmaceutical Research Center, PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi 75280, Pakistan Omar Aziz     BioFocus; Chesterford Research Park, Saffron Walden, Essex, CB10 1XL,...