Sarmento / das Neves Chitosan-Based Systems for Biopharmaceuticals

Delivery, Targeting and Polymer Therapeutics
1. Auflage 2012
ISBN: 978-1-119-96296-0
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 592 Seiten, E-Book

Chitosan is a linear polysaccharide commercially produced by thedeacetylation of chitin. It is non-toxic, biodegradable,biocompatible, and acts as a bioadhesive with otherwise unstablebiomolecules - making it a valuable component in the formulation ofbiopharmaceutical drugs.
Chitosan-Based Systems for Biopharmaceuticals provides anextensive overview of the application of chitosan and itsderivatives in the development and optimisation ofbiopharmaceuticals. The book is divided in four different parts.Part I discusses general aspects of chitosan and its derivatives,with particular emphasis on issues related to the development ofbiopharmaceutical chitosan-based systems. Part II deals with theuse of chitosan and derivatives in the formulation and delivery ofbiopharmaceuticals, and focuses on the synergistic effects betweenchitosan and this particular subset of pharmaceuticals. Part IIIdiscusses specific applications of chitosan and its derivatives forbiopharmaceutical use. Finally, Part IV presents diverse viewpointson different issues such as regulatory, manufacturing andtoxicological requirements of chitosan and its derivatives relatedto the development of biopharmaceutical products, as well as theirpatent status, and clinical application and potential.
Topics covered include:
* chemical and technological advances in chitins and chitosansuseful for the formulation of biopharmaceuticals
* physical properties of chitosan and derivatives in sol and gelstates
* absorption promotion properties of chitosan andderivatives
* biocompatibility and biodegradation of chitosan andderivatives
* biological and pharmacological activity of chitosan andderivatives
* biological, chemical and physical compatibility of chitosan andbiopharmaceuticals
* approaches for functional modification or crosslinking ofchitosan
* use of chitosan and derivatives in conventionalbiopharmaceutical dosage forms
* manufacture techniques of chitosan-based microparticles andnanoparticles for biopharmaceuticals
* chitosan and derivatives for biopharmaceutical use:mucoadhesive properties
* chitosan-based systems for mucosal delivery ofbiopharmaceuticals
* chitosan-based delivery systems for mucosal vaccination
* chitosan-based nanoparticulates for oral delivery ofbiopharmaceuticals
* chitosan-based systems for ocular delivery ofbiopharmaceuticals
* chemical modification of chitosan for delivery of DNA andsiRNA
* target-specific chitosan-based nanoparticle systems for nucleicacid delivery
* functional PEGylated chitosan systems forbiopharmaceuticals
* stimuli-sensitive chitosan-based systems forbiopharmaceuticals
* chitosan copolymers for biopharmaceuticals
* application of chitosan for anti-cancer biopharmaceuticaldelivery
* chitosan-based biopharmaceuticals scaffolds in tissueengineering and regenerative medicine
* wound healing properties of chitosan and its use in wounddressing biopharmaceuticals
* toxicological properties of chitosan and derivatives forbiopharmaceutical applications
* regulatory status of chitosan and derivatives
* patentability and intellectual property issues
* quality control and good manufacturing practice
* preclinical and clinical use of chitosan and derivatives forbiopharmaceuticals
Chitosan-Based Systems for Biopharmaceuticals is animportant compendium of fundamental concepts, practical tools andapplications of chitosan-based biopharmaceuticals for researchersin academia and industry working in drug formulation and delivery,biopharmaceuticals, medicinal chemistry, pharmacy, bioengineeringand new materials development.

Autoren/Hrsg.

Sarmento, Bruno

das Neves, Jose

Über Autor(innen)

Bruno Sarmento, Department of Pharmaceutical Technology,Faculty of Pharmacy, University of Porto, Porto, Portugal &CICS, Department of Pharmaceutical Sciences, Instituto Superior deCiências da Saúde-Norte, Gandra, Portugal
José das Neves, Department of PharmaceuticalTechnology, Faculty of Pharmacy, University of Porto, Porto,Portugal