Biology and Physiology of the Blood-Brain Barrier

Transport, Cellular Interactions, and Brain Pathologies
1996
ISBN: 978-0-306-45362-5
Verlag: Springer US

Buch, Englisch, Band 46, 388 Seiten, HC runder Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 2200 g

Reihe: Advances in Behavioral Biology

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho­ logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu­ dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

Zielgruppe

Research

Autoren/Hrsg.

Scherman, Daniel

Couraud, Pierre-Olivier

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Säugetiere (Mammalia) Beuteltiere (Monotremen)
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Säugetiere (Mammalia) Meeres- und Süßwassersäuger
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Neurochirurgie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Säugetiere (Mammalia) Primaten
• Naturwissenschaften Biowissenschaften Botanik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Introductory Overviews.- I: Physiological Transports through the Blood-Brain Barrier.- II: Blood-Brain Barrier and Drug Delivery to the Brain.- III: Multidrug Resistance P-Glycoprotein at the Blood-Brain Barrier.- IV: Signal Transduction in Brain Endothelial Cells.- V: Interactions—Leukocytes-Brain Endothelial Cells.- VI: Brain Pathologies and Blood-Brain Barrier.