Buch, Englisch, Band 985, 295 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 6592 g
Buch, Englisch, Band 985, 295 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 6592 g
Reihe: Advances in Experimental Medicine and Biology
ISBN: 978-94-024-0629-0
Verlag: Springer Netherlands
The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Zellbiologie
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Naturwissenschaften Biowissenschaften Enzymologie
- Naturwissenschaften Biowissenschaften Proteinforschung
- Naturwissenschaften Biowissenschaften Lipidologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Naturwissenschaften Biowissenschaften Kohlenhydrate
Weitere Infos & Material
1. Basic Biology of GAPDH. - 2. GAPDH and Intermediary Metabolism. - 3. Compartmentation of GAPDH. - 4. Functional Diversity. - 5. GAPDH, as a Virulence Factor. - 6. Target for Diverse Chemical Modifications. - 7. Dynamic Oligomeric Properties. - 8. Multiple Binding Partners. - 9. GAPDH in Anesthesia.
