Sherbet Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

1. Auflage 2011
ISBN: 978-0-12-387820-5
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 368 Seiten

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. - Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes - Aids the development of therapeutic treatments for cancer - Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Autoren/Hrsg.

Sherbet, G V

Inhaltsverzeichnis

1;Front Cover;1
2;Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy;4
3;Copyright Page;5
4;Contents;6
5;Preface;12
6;Abbreviations;14
7;Introduction;18
8;Chapter 1. Convergence of Growth-Factor Signalling Pathways in Developmental Systems and Pathogenesis;22
9;Chapter 2. Growth Factor Families;24
9.1;The Membrane-Receptor Binding Family of Growth Factors;24
9.2;The Intracellular-Receptor Binding Family of Ligands;26
10;Chapter 3. Growth Factors in Differentiation and Morphogenesis;28
10.1;TGF-ß Family Growth Factors in Differentiation and Morphogenesis;29
10.2;TGF-ß in Tumour Growth, Invasion and Metastases;30
10.3;The TGF-ß Signalling Cascade;31
10.4;The TGF-ß Receptor Group;32
10.5;Nodal Signalling in Development, Differentiation and Pattern Formation;52
10.6;Bone Morphogenetic Proteins;57
10.7;Growth and Differentiation Factors;66
10.8;Activin and Inhibin Signalling;73
11;Chapter 4. Vascular Endothelial Growth Factor;76
11.1;VEGF Signalling;76
11.2;Angiogenic Properties of VEGF Proximal and Distal Splice Variants;77
11.3;Synergy of VEGF with Other Angiogenic Signalling Systems;78
11.4;Neovascularisation and Tumour Progression;82
11.5;Targeting VEGF and VEGFR in Cancer Treatment;83
12;Chapter 5. Hepatocyte Growth Factor;86
12.1;Molecular Structure of HGF;86
12.2;HGF/MET Signalling;86
12.3;MET as a Therapeutic Target;90
13;Chapter 6. The Platelet-Derived Growth Factor Family;92
13.1;PDGF in Cell Transformation and Cancer;93
13.2;Relationship of PDGF Expression to Cancer Invasion and Progression;99
13.3;Genetic Changes in PDGFs and PDGFRs;100
14;Chapter 7. Nerve Growth Factors;102
14.1;NT Signalling;102
14.2;Genetic Alterations in NT Receptors;103
14.3;Expression of NTs and Their Receptors in Cancer;105
15;Chapter 8. Insulin-Like Growth Factors;108
15.1;Insulin-Like Growth Factors and Their Receptors;108
15.2;IGF Signalling Pathways;109
15.3;IGF Signalling Interacts with Other Signalling Systems;111
15.4;IGF Expression in Cancers;121
16;Chapter 9. Connective Tissue Growth Factor;126
16.1;CTGF in Wound Healing and Fibrosis;126
16.2;CTGF Expression Correlates with Cancer Progression and Prognosis;127
16.3;Is CTGF Involved in Osteotropic Metastasis?;128
16.4;Pro-angiogenic Effect of CTGF;129
16.5;Regulation of CTGF by TGF-ß;130
17;Chapter 10. Thrombospondins;132
17.1;TSPs in Cancer;133
18;Chapter 11. Cytokines;136
18.1;Tumour Necrosis Factors;136
18.2;Interleukins;140
18.3;Interferons;143
18.4;Cytokines and Myeloid Differentiation;145
18.5;Granulocyte–Macrophage (GM-CSF), Granulocyte (G-CSF) and Macrophage (M-CSF) Colony-Stimulating Factors;146
18.6;Cytokines in Cancer Therapy;147
18.7;Chemokines;149
18.8;Monocyte Chemoattractant Protein (MCP);152
19;Chapter 12. Growth Factor and Hedgehog Signalling Pathways Meet in Developmental Systems;154
19.1;The Hedgehog (Hh) Proteins;154
19.2;The Hh Signalling Cascade;155
19.3;Hh Homologues and Their Role in Morphogenesis;157
19.4;Co-operative Signalling by Hh and Growth Factors;159
20;Chapter 13. Epidermal Growth Factors and Their Signalling Systems;162
20.1;Growth Factor Signal Transduction;162
21;Chapter 14. The Epidermal Growth Factor (EGF) Family;194
21.1;Structure, Function and Expression of Epidermal Growth Factor (EGF) and EGF Receptor;194
21.2;Single Nucleotide Polymorphism of EGF and Its Significance;195
21.3;Function of Transforming Growth factor (TGF)-a;197
21.4;Neuregulins (Heregulins);199
21.5;Amphiregulin (AREG);204
21.6;Epiregulin (EREG);213
21.7;ß-Cellulin (BTC);215
21.8;Heparin-Binding Epidermal Growth Factor-Like Growth Factor;216
22;Chapter 15. The Fibroblast Growth Factor Family;220
22.1;FGFs in the Development of the Central Nervous System and Neuronal Differentiation;222
22.2;FGF2 (Basic FGF);225
22.3;FGF2-Mediated Promotion of Intercellular Adhesion;226
22.4;FGF2 and Promotion of Neurite Extension;226
22.5;FGF2 and Osteogenesis;228
22.6;FGFs 1 and 2 Regulate Cell Proliferation;229
22.7;FGFs 1 and 2 and the Induction of Angiogenesis;229
23;Chapter 16. Intracellular Receptor Binding Growth Factors;232
24;Chapter 17. The Androgens and Androgen Receptors in Development, Differentiation and Neoplasia;234
24.1;Androgen Receptor and Androgen-Responsive Elements;234
24.2;AR-Activated Signalling Pathways;235
24.3;AR Expression in Cancer Progression;237
24.4;Functional Integrity of AR and AR-Mediated Signalling;238
24.5;Interaction of Androgen and Growth Factor Signalling;238
25;Chapter 18. Vitamin D[sub(3)] in Cell Proliferation, Apoptosis and Differentiation;240
25.1;The VD3 Receptor, VDRs and VDR Response Elements;240
25.2;VDR Signalling in Cell Proliferation, Apoptosis and Differentiation;241
25.3;Modulation of Cell Adhesion and Motility;242
25.4;Collaborative Function of VDR and RA Receptors;244
26;Chapter 19. Retinoids in Development and Pattern Formation;246
26.1;Retinoic Acid Receptors;246
26.2;RAR-Mediated Biological Effects;246
27;Chapter 20. Oestrogens and Progesterone in Normal Physiology and Neoplasia;250
27.1;Receptor Mediation of Oestrogen and Progesterone Function;250
27.2;ER/PR in Cell Adhesion, Proliferation and Cross-talk with Growth Factor Signalling;251
27.3;ER/PR Cross-talk with Tumour Suppressor and Promoter Signalling;253
27.4;The Trefoil Protein TFF1;255
28;Chapter 21. Glucocorticoid Signalling in Normal and Aberrant Physiology;258
28.1;Glucocorticoid Receptors in Signalling;258
28.2;Effects of Glucocorticoids on Cell Function;260
29;Epilogue;264
30;References;270