Lupeol

Therapeutic Applications in Human Health and Disease
1. Auflage 2025
ISBN: 978-1-032-98695-1
Verlag: Taylor & Francis Ltd

Buch, Englisch, 308 Seiten, Format (B × H): 178 mm x 254 mm

This book explores the therapeutic potential of Lupeol, a naturally occurring triterpenoid. The introductory chapters present its physicochemical properties, chemical modifications, and synthetic analogs, highlighting its potential against various diseases. The beneficial effects of Lupeol are explored across a broad range of health conditions, including its role in skin diseases and cardioprotective effects. The book highlights its antioxidant, anti-inflammatory, and chemopreventive effects, including its use in nanoparticle formulations for enhanced efficacy. Its protective properties for the kidneys, liver, and brain are also explored, along with its ability to sensitize resistant cells to chemotherapy and radiation. The chapters discuss the antimicrobial, antiparasitic, and anti-cancer effects of Lupeol, its role in inhibiting tumor growth, angiogenesis, and metastasis, and its modulation of transcription factors involved in disease pathways. Traditional uses of Lupeol-containing plants in systems like Unani medicine and its influence on gut microbiota and postbiotics for disease management are examined. Towards the end, the book also addresses Lupeol's safety, toxicology, and future clinical potential.

Key Features:

- Examines the therapeutic potential of Lupeol, a naturally occurring triterpenoid, through its diverse health applications

- Presents the physicochemical properties, chemical modifications, and synthetic analogs of Lupeol

- Highlights the antioxidant, anti-inflammatory, and chemopreventive effects of Lupeol and its role in nanoparticle formulations for enhanced efficacy in cancer treatments.

- Explores the cardioprotective, nephroprotective, hepatoprotective, and neuroprotective properties of Lupeol

- Addresses the safety, toxicology, and future clinical applications of Lupeol

It is a useful resource for researchers and students in pharmaceutical sciences, ethnopharmacology, and traditional medicine.

Zielgruppe

Postgraduate and Professional Reference

Autoren/Hrsg.

Siddique, Hifzur R

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Naturwissenschaften Biowissenschaften Mikrobiologie

Inhaltsverzeichnis

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Chemical Alchemy of Lupeol: Synthesis, Derivatives Variability, and Physiochemical Properties. 2. The Cardioprotective Effect of Pentacyclic Triterpene Lupeol: Current Status and Future Prospects. 3. Beneficial Effects of Lupeol Against Different Skin Diseases: Current Research and Future Direction. 4. Antioxidant and Anti-inflammatory Role of Triterpene Lupeol. 5. Chemopreventive Effect of Lupeol and Lupeol Nanoparticles. 6. Beneficial Hepatoprotective Effect of Triterpene Lupeol: Present Status and Future Perspectives. 7. The Therapeutic and Protective Potential of Lupeol in Immune Modulation and Disease Prevention. 8. The Beneficial Effect of Lupeol Against Diabetes and Obesity. 9. Chemosensitivity and Radiosensitivity of Triterpene Lupeol: Current Status and Future Perspectives. 10. Cell Growth Regulation and Molecular Targets of Lupeol. 11. The Neuroprotective Effects of Lupeol. 12. Triterpene Lupeol as Antimicrobial Agents. 13. Antitumor, Anti-angiogenesis, Anti-invasion, and Antimetastatic Effects of Lupeol. 14. Roles of Lupeol Rich Food on Gut Microbiota and Postbiotics in Human Diseases. 15. Lupeol: A Natural Supplement for Enhanced Health. 16. Safety and Toxicological Studies of Lupeol in Different Experimental Models. 17. Importance of Lupeol Containing Plants and Plant Products in Traditional Medicine with an Emphasis on the Unani System of Medicine. 18. Future Perspectives of Lupeol for Clinical Trials and Improvement of Activity.

Über Autor(innen)

Dr. Siddique is working as a Senior Assistant Professor at Aligarh Muslim University (AMU), India. He obtained his Ph.D. in 2008 from the Indian Institute of Toxicology Research, India. He got post-doctoral training at the University of Wisconsin, the University of Minnesota, and the University of S. California, USA. His research specializations are Cancer Biology and molecular Pharmacology/Toxicology. He is now the Programme Director of the Molecular Cancer Genetics and Translational Research program at AMU. He so far published more than 103 original research papers in journals like Nature Communications, Hepatology, Stem Cells, Clinical Cancer Research, Cancer Research, Genes and Cancer, Seminars in Cancer Biology, Seminars in Cell and Developmental Biology, Cell Death Discovery, Cor-ordination Chemistry Reviews, Molecular Cancer Therapeutics, etc. He has 01 patent, two edited books, 20 chapters, and has delivered numerous invited talks. He is the recipient of more than 42 academic awards/honors, such as the SBUR-Young Scientist Travel Award, USA; IABS-Outstanding Cancer Research Award, India; SPER-Innovative Researcher Award, India; “AEDS-Distinguish Scientist Award,” India; Sir Syed Outstanding Researcher of the Year-2022, etc. He is a FELLOW of the Biotech Research Society of India and a life member of the National Academy of Sciences and National Academy of Medical Sciences, India, the American Association of Cancer Research, the Indian Association for Cancer Research, etc. He has served nationally and internationally as a grant reviewer of the Czech Science Foundation, Czech Republic; Health Research Board (IRB), Ireland; Council of Scientific and Industrial Research, India; the Department of Science and Technology, India; Department of Biotechnology, India. He is a peer reviewer for more than 100 journals, including Genetics, i-Science, Life Sciences, BBA-Reviews on Cancer, Frontiers Genetics, Cancer Medicine, Chemosphere, Frontiers Oncology, Cancer Cell International, Physica E, Hepatic Oncology, Food and Chemical Toxicology, Redox Report, Drug Discover, Computers in Biology and Medicine, etc. He is an editorial board member/ guest editor of 15 journals, such as Recent Patents on Anticancer Drug Discovery, Frontiers in Oncology, Frontier Genetics, Cancer, Cancers, Metastasis Reviews, etc.  Recently, he has been one of the members of a group of 101 experts from different countries who have come to an expert consensus on diagnosing and treating NUT carcinoma using a multidisciplinary approach. He has supervised many post-doctoral fellows, Ph.D., MS/MD students, project fellows, and M.Sc./undergraduate students. In addition, his research works are cited in journals like Nature, Nature Genetics, Nature Medicine, Cancer Cell, Cancer Discovery, Cell Stem Cells, Stem Cells, PNAS, Science Translational Medicines, etc. He writes popular articles on various scientific problems and social issues for the mass population and appears in TV interviews and live social media to discuss different scientific problems.