Soboloff / Kappes Signaling Mechanisms Regulating T Cell Diversity and Function

1. Auflage 2017
ISBN: 978-1-4987-0509-7
Verlag: CRC Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 274 Seiten

Reihe: Methods in Signal Transduction Series

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Zielgruppe

This book is intended for molecular biologists, cell biologists, and immunologists. It also would be useful to graduate students, faculty, and researchers interested in T cells, and for use in libraries at universities, research institutions, and pharmaceutical companies.

Autoren/Hrsg.

Soboloff, Jonathan

Kappes, Dietmar J.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

T cell origins, interactions and roles in adaptive immunity. Mechanisms regulating progression through DN stages. Positive selection. Negative selection. ThPok in cd4/cd8 selection. Directing cells into Gamma/Delta variants. Tregs. iNKT. Early events in T cell receptor engagement. T cell engagement and the Immunological Synapse. Orai1-mediated Ca2+ entry and T cell activation. Transcriptional mechanisms modulating Ca2+ signals during T cell activation. IFNs and Differentiation to Th1 cells.

Über Autor(innen)

Jonathan Soboloff, Ph.D, is an associate professor in the Department of Biochemistry in the School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

Dietmar Kappes, Ph.D, is a professor and director of the Fox Chase Cancer Center in Philadelphia, Pennsylvania, USA.