Speck X-Ray Contrast Media

Overview, Use and Pharmaceutical Aspects
3rd Auflage 1991
ISBN: 978-3-662-02709-7
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 53 Seiten, eBook

Short presentation of aspects important for the application
of X-ray contrast media: Composition and properties of
contrast media, handling with respect to stability, purity
and sterility; applications, interaction, risks; drugs for
prophylaxis and treatment of side effects.

Zielgruppe

Research

Autoren/Hrsg.

Speck, Ulrich

Weitere Mitwirkende

Behrends-Steins, B.

Blaszkiewicz, P.

Hempel, H.-E.

Herrmann, D.

Hübner-Steiner, U.

Lenzner, A.

Mützel, W.

Post, E.

Steins, H.

Taenzer, V.

Inhaltsverzeichnis

General principles.- Structure and properties of X-ray contrast media.- Barium sulfate.- Water-soluble contrast media.- Physicochemical properties of water-soluble contrast media.- Water solubility.- Viscosity/temperature.- Osmolality.- Lipophilia.- Electrical charge.- Possible uses of contrast media.- Principles of opacification.- Pharmaceutical product quality.- Practical information at a glance.- Purity of the active ingredient, by- and degradation products.- Formulations.- Additives.- Microbiological quality of the finished product.- Sterile filtration, ultrafiltration and sterilization.- Sterility test.- Test for pyrogens.- Preservation of product quality in hospitals and practices.- Stability in long-term storage and at different temperatures.- Sensitivity to irradiation and light.- Tests for contamination with particles.- Risks of microbial contamination.- Transferring the contrast medium to sterile containers, disposable syringes, automatic injectors.- Resterilization.- Influence on laboratory tests.- Interactions with medicines.- Risk of contrast media use.- General reactions (anaphylactoid reactions).- Prophylaxis of general reactions.- Dose-dependent side effects.- Prophylaxis and therapy of severe iodine-induced hyperthyroidism.- Renal damage.- Pregnant patients.- Breast-feeding mothers.- Pheochromocytoma.- Sickle-cell anemia.- Drugs and measures for the treatment of a contrast medium reaction.- Further development of contrast media.- References.- Commercial brands and their iodine content (g).