The Human Hypothalamus

Neuroendocrine Disorders Volume 181
Erscheinungsjahr 2021
ISBN: 978-0-12-820683-6
Verlag: Elsevier Science

Buch, Englisch, 566 Seiten, Format (B × H): 195 mm x 260 mm, Gewicht: 1480 g

The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders.

Zielgruppe

Clinical neurologists, researchers in neurology

Autoren/Hrsg.

Swaab, Dick F

Buijs, Ruud M.

Lucassen, Paul J.

Salehi, Ahmad

Kreier, Felix

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

1. Introduction: The human hypothalamus and neuroendocrine disorders SECTION 15 Structural disorders of the hypothalamo-pituitary region 2. Pituitary stalk interruption syndrome 3. Empty sella syndrome: Multiple endocrine disorders 4. Pituitary dysfunction after aneurysmal subarachnoidal hemorrhage 5. Septo-optic dysplasia SECTION 16 Tumors of the hypothalamus 6. Hypothalamic hormone-producing tumors 7. Craniopharyngiomas primarily affecting the hypothalamus SECTION 17 Neuroimmunological disorders 8. The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects 9. Neuroendocrine manifestations of Langerhans cell histiocytosis 10. Neuroendocrine manifestations of Erdheim-Chester disease 11. Hypothalamitis and pituitary atrophy 12. Narcolepsy Type I as an autoimmune disorder 13. Neuromyelitis optica, aquaporin-4 antibodies, and neuroendocrine disorders 14. Antibodies against the pituitary and hypothalamus in boxers 15. Autoimmune diabetes insipidus SECTION 18 Drinking disorders 16. Neuroimaging of central diabetes insipidus 17. Differential diagnosis of familial diabetes insipidus 18. The vasopressin-aquaporin-2 pathway syndromes 19. Adipsic diabetes insipidus 20. Animal models for diabetes insipidus 21. Nocturnal enuresis in children: The role of arginine-vasopressin SECTION 19 Eating disorders 22. Monogenic human obesity syndromes 23. Hypothalamic microinflammation 24. Glucose and fat sensing in the human hypothalamus 25. Hypothalamus and neuroendocrine diseases: The use of human-induced pluripotent stem cells for disease modeling 26. Prader-Willi syndrome: Hormone therapies 27. Transcriptomics of the Prader-Willi syndrome hypothalamus 28. Disorders of hypothalamic function: Insights from Prader-Willi syndrome and the effects of craniopharyngioma 29. Animal models for Prader-Willi syndrome 30. Is there a hypothalamic basis for anorexia nervosa? SECTION 20 Reproduction, olfaction and sexual behavior 31. Sexual differentiation of the human hypothalamus: Relationship to gender identity and sexual orientation 32. Klinefelter syndrome or testicular dysgenesis: Genetics, endocrinology, and neuropsychology 33. Neurobiology of puberty and its disorders

Über Autor(innen)

Lucassen, Paul J.
Paul J. Lucassen did his PhD in 1995 on Alzheimer's Disease at the Netherlands Institute for Brain Research in Amsterdam.
After a.o. a postdoc in Leiden, he became Full Professor of Brain Plasticity in 2011 at the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam, The Netherlands.
His group studies molecular, nutritional, pharmacological and environmental regulation of brain plasticity. They combine molecular tools, in vitro/vivo model systems, human brain tissue, cohort studies and brain imaging. A major focus is on adult neurogenesis and cognition in relation to; (early life) stress, exercise, enrichment, depression, brain insults and dementia.

Buijs, Ruud M.
Dr. Ruud M. Buijs is head of the Physiology department of the I.I.Biomedicas at the UNAM university and leader of the group Hypothalamic Integration Mechanisms. In that group, the scientists study how the brain and body interact with each other, and hereby the attention is focussed on autonomic and hormonal regulation of body functions under the influence of the biological clock of the brain.

Kreier, Felix
Felix Kreier is a pediatrician and affiliated with OLVG Hospitals in Amsterdam, The Netherlands.

Salehi, Ahmad
Ahmad Salehi is affiliated with Stanford Medical School, Department of Psychiatry & Behavioral Sciences, in Palo Alto, CA, United States.