The Human Hypothalamus

Anterior Region Volume 179
Erscheinungsjahr 2021
ISBN: 978-0-12-819975-6
Verlag: Elsevier Science

Buch, Englisch, 542 Seiten, Format (B × H): 192 mm x 262 mm, Gewicht: 1440 g

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus.

Zielgruppe

Clinical neurologists, researchers in neurology

Autoren/Hrsg.

Swaab, Dick F

Kreier, Felix

Lucassen, Paul J.

Salehi, Ahmad

Buijs, Ruud M.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie

Inhaltsverzeichnis

SECTION 1� Introduction
1. Introduction: The anterior hypothalamus�
2. History of hypothalamic research: "The spring of primitive existence��
3. Anatomy and cytoarchitectonics of the human hypothalamus�
4. Morphology and distribution of hypothalamic peptidergic systems�
5. MRI maps, segregation, and white matter connectivity of the human hypothalamus in health�
6. Magnetic resonance imaging of the hypothalamo-pituitary region�
7. Resting-state functional connectivity of the human hypothalamus�
8. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology�
9. Matching of the postmortem hypothalamus from patients and controls�
SECTION 2� The basal forebrain cholinergic system
10. Spatial topography of the basal forebrain cholinergic projections: Organization and vulnerability to degeneration�
11. The diagonal band of Broca in health and disease�
12. Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease�
13. Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease�
14. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease
SECTION 3� The circadian system
15. The circadian system: From clocks to physiology�
16. Development of the circadian system and relevance of periodic signals for neonatal development�
17. Disrupted circadian rhythms and mental health�
18. Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease�
19. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities�
20. The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy�
21. Retina and melanopsin neurons�
22. Melatonin and the circadian system: Keys for health with a focus on sleep
23. Melatonin receptors, brain functions, and therapies�
24. Chronotherapy�
25. The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics�
SECTION 4� Bed nucleus of the stria terminalis and the fear circuit
26. Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function�
27. Functional anatomy of the bed nucleus of the stria terminalis-hypothalamus neural circuitry: Implications for valence surveillance, addiction, feeding, and social behaviors�
28. Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions�
SECTION 5� Preoptic area
29. The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis
30. The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies�
31. The intermediate nucleus in humans: Cytoarchitecture, chemoarchitecture, and relation to sleep, sex, and Alzheimer disease

Über Autor(innen)

Lucassen, Paul J.
Paul J. Lucassen did his PhD in 1995 on Alzheimer's Disease at the Netherlands Institute for Brain Research in Amsterdam.
After a.o. a postdoc in Leiden, he became Full Professor of Brain Plasticity in 2011 at the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam, The Netherlands.
His group studies molecular, nutritional, pharmacological and environmental regulation of brain plasticity. They combine molecular tools, in vitro/vivo model systems, human brain tissue, cohort studies and brain imaging. A major focus is on adult neurogenesis and cognition in relation to; (early life) stress, exercise, enrichment, depression, brain insults and dementia.

Kreier, Felix
Felix Kreier is a pediatrician and affiliated with OLVG Hospitals in Amsterdam, The Netherlands.

Salehi, Ahmad
Ahmad Salehi is affiliated with Stanford Medical School, Department of Psychiatry & Behavioral Sciences, in Palo Alto, CA, United States.

Buijs, Ruud M.
Dr. Ruud M. Buijs is head of the Physiology department of the I.I.Biomedicas at the UNAM university and leader of the group Hypothalamic Integration Mechanisms. In that group, the scientists study how the brain and body interact with each other, and hereby the attention is focussed on autonomic and hormonal regulation of body functions under the influence of the biological clock of the brain.