Chesley's Hypertensive Disorders in Pregnancy

5th Auflage
ISBN: 978-0-12-818417-2
Verlag: Elsevier Science

Buch, Englisch, 486 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 1340 g

Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.

Autoren/Hrsg.

Taylor, Robert N

Roberts, James M

Davidge, Sandra T.

Conrad, Kirk P

Staff, Anne Cathrine

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Nephrologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gynäkologie, Geburtshilfe
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie

Inhaltsverzeichnis

1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy

2. Epidemiology of Pregnancy-Related Hypertension

3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia

4. Preconceptional and Periconceptional Pathways to Preeclampsia

5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies

6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome

7. The Immunology of Preeclampsia

8. Trophoblast Extracellular Vesicles in Preeclampsia

9. Angiogenesis and Preeclampsia

10. Vascular Endothelial Cell Dysfunction in Preeclampsia

11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy

12. Cardiometabolic Antecedents of Preeclampsia

13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia

14. The Kidney in Normal Pregnancy and Preeclampsia

15. Salt, Aldosterone, and the Renin- Angiotensin System in Pregnancy

16. Platelets, Coagulation, and the Liver

17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy

18. Prediction and Prevention of Preeclampsia

19. Long-Term Effects of Preeclampsia on Mothers and Offspring

20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets

21. Harmonization of Data and Biobanks for Preeclampsia Research

Über Autor(innen)

Davidge, Sandra T.
Dr. Davidge is a Distinguished University Professor in the Faculty of Medicine & Dentistry at the University of Alberta and Executive Director of the Women and Children's Health Research Institute, Edmonton, Alberta, Canada. Davidge received her PhD from the University of Vermont and completed her postdoctoral fellowship training at the Magee Womens Research Institute in Pittsburgh, PA, USA. Davidge's research program is focused on understanding mechanisms for vascular dysfunction in pregnancy complications, particularly preeclampsia, and subsequent impact on later-life cardiovascular health. Her fundamental studies are currently focused on developing early intervention strategies for improving pregnancy outcomes to enhance life-long maternal and offspring cardiovascular health. Davidge is a Fellow in the Canadian Academy of Health Science and a past president of Society for Reproductive Investigation (2017-2018).

Taylor, Robert N
Robert N. Taylor, MD, PhD is Professor of Obstetrics and Gynecology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY. Previously, he was Professor of Obstetrics and Gynecology at The University of Utah, Wake Forest School of Medicine, Emory University, and Director of the Center for Reproductive Sciences at the University of California, San Francisco. Taylor received his undergraduate education at Stanford University and the combined MD-PhD at Baylor College of Medicine. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist whose major research foci have included the role of placental angiogenesis and endothelial cell activation in preeclampsia, and the molecular actions of estrogen and progesterone on endometrial differentiation and neuroangiogenesis as they relate to endometriosis. Dr. Taylor served on executive committees of the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, the World Endometriosis Society and the California Institute for Regenerative Medicine.

Roberts, James M
Dr. Roberts' research is interdisciplinary and involves fundamental, clinical, behavioral and epidemiological studies. He has been involved in several seminal studies of preeclampsia including the recognition of preeclampsia as involving endothelial dysfunction and being more than hypertension in pregnancy. He currently is involved in global health research as part of the Global Pregnancy Collaboration, a consortium of 40 centers world-wide that facilitates collaborative research. He is a co-investigator on studies in Brazil and South Africa. He chaired the ACOG Hypertension Task Force and was co-chair of the NHLBI NIH workshop on research on pregnancy hypertension.