The Alkaloids

Chemistry and Biology
1. Auflage 2003
ISBN: 978-0-08-052149-7
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band Volume 60, 414 Seiten

Reihe: The Alkaloids

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than forty years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. - Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective - Comprehensive dynamic reviews written by the leading authors in the respective fields - Broader coverage than before on the biological aspects

Autoren/Hrsg.

Inhaltsverzeichnis

1;Front Cover;1
2;The Alkaloids: Chemistry and Biology;4
3;Copyright Page;5
4;Contents;6
5;Contributors;8
6;Preface;10
7;Chapter 1. Clinical Studies of Camptothecin and Derivatives;12
7.1;I. Introduction;12
7.2;II. Mechanisms of Action;14
7.3;III. Mutagenicity and Resistance Mechanisms;18
7.4;IV. Irinotecan;20
7.5;V. Topotecan;30
7.6;VI. Considerations of Route of Administration;38
7.7;VII. Investigational Derivatives;40
7.8;VIII. Conclusions;44
7.9;References.;46
8;Chapter 2. Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids;62
8.1;I. Introduction;62
8.2;II. Isolation;64
8.3;III. Synthesis;136
8.4;IV. Biosynthesis;155
8.5;V. Structure and Tremorgenicity;166
8.6;References;169
9;Chapter 3. The Daphniphyllum Alkaloids;176
9.1;I. Introduction;176
9.2;II. Structures of Representative Alkaloids;181
9.3;III. Biosynthesis and Biogenesis;195
9.4;IV. Synthesis;204
9.5;V. Conclusions;213
9.6;References;214
10;Chapter 4. The Manzamine Alkaloids;218
10.1;I. Introduction;218
10.2;II. Isolation and Structure Elucidation from Marine Sponges;225
10.3;III. Biogenesis and Biosynthesis;234
10.4;IV. Synthesis;275
10.5;V. Pharmacology;281
10.6;VI. Conclusions;288
10.7;References;289
11;Chapter 5. Sesquiterpene Pyridine Alkaloids;298
11.1;I. Introduction;298
11.2;II. Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives;300
11.3;III. Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives;318
11.4;IV. Edulinate Sesquiterpene Pyridine Alkaloids;326
11.5;V. Cassinate Sesquiterpene Pyridine Alkaloids;328
11.6;VI. Lower Molecular Weight Sesquiterpene Pyridine Alkaloids.;328
11.7;VII. Non-Celastraceous Sesquiterpene Pyridine Alkaloids;329
11.8;VIII. Biosynthesis and Biogenesis ;333
11.9;IX. Biological Activity;341
11.10;X. Taxonomic Considerations;345
11.11;XI. Synthesis;345
11.12;References;350
12;Chapter 6. Chemical and Biological Aspects of Melanin;356
12.1;I. Introduction;356
12.2;II. Biogenesis of Melanin;358
12.3;III. Natural Melanins;365
12.4;IV. Investigations of Melanins by Physical Methods;384
12.5;V. Synthetic Melanins;387
12.6;VI. Physicochemical Properties and Biological Functions of Melanins;390
12.7;References;395
13;Index;404