Toone Advances in Enzymology and Related Areas of Molecular Biology, Volume 77

1. Auflage 2011
ISBN: 978-0-470-92052-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 77, 432 Seiten, E-Book

Reihe: Advances in Enzymology - and Related Areas of Molecular Biology

This book covers important advances in enzymology, explainingthe behavior of enzymes and how they can be utilized to developnovel drugs, synthesize known and novel compounds, and understandevolutionary processes.

Autoren/Hrsg.

Toone, Eric J.

Inhaltsverzeichnis

Contributors.
Preface.
Structure and Mechanism of RND-Type Multidrug Efflux Pumps(Hiroshi Nikaido).
Efflux Pumps of Gram-Negative Bacteria: Genetic Responses toStress and the Modulation of Their Activity by pH, Inhibitors, andPhenothiazines (Leonard Amaral, Seamus Fanning, and Jean-MariePagès).
Efflux Pumps of the Resistance-Nodulation-DivisionFamily: A Perspective of Their Structure, Function, and Regulationin Gram-Negative Bacteria (Mathew D. Routh, Yaramah Zalucki,Chih-Chia Su, Feng Long, Qijing Zhang, William M. Shafer, andEdward W. Yu).
The MFS Efflux Proteins of Gram-Positive and Gram-NegativeBacteria (Massoud Saidijam, Kim E. Bettaney, Dong Leng, PikyeeMa, Zhiqiang Xu, Jeffrey N. Keen, Nicholas G. Rutherford, AlisonWard, Peter J. F. Henderson, Gerda Szakonyi, Qinghu Ren, Ian T.Paulsen, Ingerid Nes, Jasmin K. Kroeger, and Anne-BritKolsto).
Efflux Pumps as an Important Mechanism for Quinolone Resistance(Jordi Vila, Anna Fabrega, Ignasi Roca, Alvaro Hernandez, andJose Luis Martinez).
Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update(Ravi D. Barabote, Jose Thekkiniath, Richard E. Strauss,Govindsamy Vediyappan, Joe A. Fralick, and Michael J. SanFrancisco).
A Survey of Oxidative Paracatalytic Reactions Catalyzed byEnzymes That Generate Carbanionic Intermediates: Implications forROS Production, Cancer Etiology, and Neurodegenerative Diseases(Victoria I. Bunik, John V. Schloss, John T. Pinto, NataliaDudareva, and Arthur J. L. Cooper).
Author Index.
Subject Index.

Über Autor(innen)

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is also the Deputy Director for Technology for the Advanced Research Projects Agency-Energy (ARPA-E) of the Department of Energy and directs the ARPA-E's Electrofuels program.