Toone Advances in Enzymology and Related Areas of Molecular Biology, Volume 78

1. Auflage 2011
ISBN: 978-1-118-10580-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 78, 560 Seiten, E-Book

Reihe: Advances in Enzymology - and Related Areas of Molecular Biology

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.

Autoren/Hrsg.

Toone, Eric J.

Inhaltsverzeichnis

Contributors vii
Preface ix
Structure and Regulation of Type 2 Transglutaminase in Relationto Its Physiological Functions and Pathological Roles 1
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and MartinGriffin
Physiopathological Roles of Human Transglutaminase 2 47
Vittorio Gentile
Transglutaminase in Epidermis and Neurological Disease or WhatMakes a Good Cross-Linking Substrate 97
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, andPhilippe Djian
Transglutaminase 2: A New Paradigm for NF-B Involvement inDisease 161
Soo-Youl Kim
Transglutaminase 2 At the Crossroads between Cell Death andSurvival 197
Mauro Piacentini, Manuela D'Eletto, Laura Falasca, MariaGrazia Farrace, and Carlo Rodolfo
Tissue Transglutaminase and Its Role in Human Cancer Progression247
Bo Li, Richard A. Cerione, and Marc Antonyak
Transglutaminase 2 Dysfunctions in the Development of AutoimmuneDisorders: Celiac Disease and TG2-/-Mouse 295
Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and LaszloFesus
Effects and Analysis of Transglutamination on ProteinAggregation and Clearance in NeurodegenerativeDiseases 347
Zoltan Nemes
Transglutaminase-Mediated Remodeling of the Human ErythrocyteMembrane Skeleton: Relevance for Erythrocyte Diseases withShortened Cell Lifespan 385
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE,Oksana Lockridge, and Athar H. Chishti
Irreversible Inhibitors of TissueTransglutaminase 415
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani,Olivier Leogane, and Christophe Pardin
Methionine Adenosyltransferase (S-AdenosylmethionineSynthetase) 449
Maria A. Pajares and George D. Markham
Index 523

Über Autor(innen)

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency--Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.