Biomedical Chemistry

Applying Chemical Principles to the Understanding and Treatment of Disease
1. Auflage 2000
ISBN: 978-0-471-32633-5
Verlag: Wiley

Buch, Englisch, 432 Seiten, Format (B × H): 162 mm x 246 mm, Gewicht: 780 g

Dieser Band schlägt eine Brücke zwischen traditionellen Studienplänen der Chemie und Anwendungen aus dem Grenzgebiet zur Biologie. Die gegenwärtigen Highlights der biomedizinischen Forschung werden ausführlich erläutert und die zugrunde liegenden chemischen Prinzipien erklärt. Unter anderem beschäftigen sich die einzelnen Kapitel mit der Wirkstofforschung auf der Basis von Mechanismen, mit dem Design neuartiger antiviraler und Antitumor-Wirkstoffe und dem magnetischen Transport von Wirkstoffen zu Tumoren. (03/00)

Autoren/Hrsg.

Torrence, Paul F

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

DRUG DISCOVERY AND DEVELOPMENT LEADS FROM FUNDAMENTALS OF ENZYME TRANSFORMATIONS AND MECHANISMS.

Sleeping Sickness: Irreversible Inhibitors of S-Adenosylmethionine Decarboxylase as Antitrypanosomal Agents (P. Woster).

Mechanism-Based S-Adenosyl-L-Homocysteine Hydrolase Inhibitors in the Search For Broad-Spectrum Antiviral Agents (D. Yin, et al.).

Alcoholism: Aldehyde Dehydrogenase Inhibitors as Alcohol Deterrent Agents (H. Nagasawa, et al.).

AIDS: Adenosine Deaminase-Activated Prodrugs for the Treatment of Huamn Immunodeficiency Virus in the Central Nervous System (J. Driscoll).

Anti-HIV Phosphotriester Pronucleotides: Basis for the Rational Design of Biolabile Phosphate Protecting Groups (C. Perigaud, et al.).

EXPLORATION OF FUNDAMENTAL CHEMICAL PRINCIPLES IN DRUG DESIGN AND DISCOVERY.

AIDS: Potential Inhibitors of Human Immunodeficiency Virus Replication (G. Kenyon).

From Chemical Warfare Agent to Anticancer Drug: The Chemistry of Phosphoramide Mustard (S. Ludeman).

Phosphoryltyrosyl Mimetics as Signaling Modulators and Potential Antitumor Agents (T. Burke, et al.).

Targeting Tumors Using Magnetic Drug Delivery (S. Pulfer & J. Gallo).

Cancer: Superacid Generation of New Antitumor Agents (J.-C. Jacquesy & J. Fahy).

Fluorine Substitution as a Modulator of Biological Processes (K. Kirk).

UNDERSTANDING THE CHEMICAL BASIS OF DRUG ACTION AND DISEASE.

Thiouracil and Related Thioureylene Compounds as Melanoma-Seekers: Paradigms for a Chemical Approach to the Design of Targeting Anticancer Agents (M. d'Ischia & G. Prota).

Carbon-Centered Radicals and Rational Design of New Antimalarial Peroxide Drugs (G. Posner, et al.).

The Chemistry of Parkinson's Disease (G. Dryhurst, et al.).

NOVEL CHEMISTRIES IN THE VANGUARD OF BIOTECHNOLOGY AND DRUG DISCOVERY.

New Generation of DNA Chips Based on Real-Time Biomimetic Recognition (F. Garnier).

Peptide Nucleic Acids (PNA): Towards Gene Therapeutic Drugs (P. Nielsen).

Ribozyme Mimics: The Evolution of Gene-Specific Chemotherapy (T. Osiek, et al.).

Index.

Über Autor(innen)

PAUL F. TORRENCE, PhD, is Professor and Chair of Chemistry at Northern Arizona University in Flagstaff, and formerly Chief of the Biomedical Chemistry Section, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Director of the Foundation for Advanced Education in the Sciences Graduate School at the National Institutes of Health. Dr. Torrence is widely recognized for his contributions to medicinal chemistry and has published more than 190 scientific papers and patents.