Vande Woude / Klein Advances in Cancer Research

1. Auflage 2010
ISBN: 978-0-12-380891-2
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 109, 160 Seiten

Reihe: Advances in Cancer Research

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Autoren/Hrsg.

Vande Woude, George F.

Klein, George

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Cancer Research;4
3;Copyright Page;5
4;Contents;6
5;Contributors;8
6;Chapter 1: Mechanisms of Prostate Cancer Initiation and Progression;10
6.1;I. Epidemiologic Studies in Prostate Cancer;11
6.2;II. The Architecture of the Normal Prostate Gland;16
6.3;III. Development and Maintenance of the Prostate Gland;20
6.4;IV. Morphological and Cytological Changes that Take Place During Prostate Cancer Initiation and Progression;22
6.5;V. Early Genetic and Epigenetic Events in the Transition from Normal Prostate to PIN and Invasive Cancer;28
6.6;VI. Transition to High-Grade Carcinoma and Metastasis;33
6.7;VII. Mechanisms of Castration-Resistant Prostate Cancer;36
6.8;VIII. Summary and Future Directions;40
6.9;Acknowledgments;41
6.10;References;41
7;Chapter 2: Genetic Basis for Susceptibility to Lung Cancer: Recent Progress and Future Directions;60
7.1;I. Introduction: Overview of Studies on Genetic and Environmental Factors Involved in Lung Cancer Susceptibility;61
7.2;II. Differences in the Process of Lung Cancer Development Between Smokers and Never-Smokers;62
7.3;III. Candidate Gene Association Studies;65
7.4;IV. Genome-Wide Association Studies;68
7.5;V. Assessment of Lung Cancer Risk in Each Individual by Combined Genotypes (Gene-Gene Interactions);71
7.6;VI. Smoking-Associated Differences (Gene-Environment Interactions);72
7.7;VII. Necessity of Further Association Studies;74
7.8;VIII. Future Directions;76
7.9;Acknowledgments;77
7.10;References;77
8;Chapter 3: Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4;82
8.1;I. Introduction;83
8.2;II. Phylogenetic Evolution, Structure, and Tissue Distribution of CSPG4;85
8.3;III. Functional Properties of CSPG4;97
8.4;IV. Clinical Applications of CSPG4;112
8.5;V. Conclusion;116
8.6;Acknowledgments;119
8.7;References;119
9;Chapter 4: KRAS Signaling Pathway Alterations in Microsatellite Unstable Gastrointestinal Cancers;132
9.1;I. Mismatch Repair, MSI, and Related Target Genes;133
9.2;II. MSI-H Phenotype-Related Molecular and Clinicopathologic Features ;133
9.3;III. MSI-H-Related Epigenetic Features: CpG island Methylator Phenotype;136
9.4;IV. MSI-H-Related Genetic Features: The KRAS Signaling Pathway ;138
9.5;V. A Serrated Carcinogenesis Pathway in the Origin of Sporadic MSI CRC;142
9.6;VI. Conclusions;145
9.7;References;145
10;Index;154