Verbeek / de Waal / Vinters Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders

Erscheinungsjahr 2013
ISBN: 978-94-017-1007-7
Verlag: Springer Netherland
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 358 Seiten, eBook

Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).

Zielgruppe

Research

Autoren/Hrsg.

Verbeek, M.M.

de Waal, R.M.

Vinters, Harry V.

Inhaltsverzeichnis

Section I: Clinical Aspects of CAA and CAA-Related Hemorrhage.- 1 Clinical aspects and diagnostic criteria of sporadic CAA-related hemorrhage.- 2 Diagnosis of CAA during life. Neuroimaging of CAA.- 3 Vascular risk factors for Alzheimer’s disease. An epidemiologic perspective.- 4 Cerebral microvascular and macrovascular disease in the aging brain; similarities and differences.- Section II: Genetics of CAA.- 5 ApoE genotype in relation to sporadic and Alzheimer-related CAA.- 6 Clinical and genetic aspects of hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D).- 7 Genetics and neuropathology of hereditary cystatin C amyloid angiopathy (HCCAA).- Section III: Cellular and Molecular Pathology of CAA.- 8 Neuropathologic features and grading of Alzheimer-related and sporadic CAA.- 9 Chemical analysis of amyloid ? protein in CAA.- 10 Immunohistochemical analysis of amyloid ? protein isoforms in CAA.- 11 Blood Brain Barrier dysfunction and cerebrovascular degeneration in Alzheimer’s disease.- 12 A?-associated proteins in cerebral amyloid angiopathy.- 13 Neuropathology of hereditary cerebral hemorrhage with amyloidosis-Dutch type.- 14 Neuropathology and genetics of prion protein and British cerebral amyloid angiopathies.- Section IV: In Vitro and Animal Models of CAA.- 15 Amyloid ? protein internalization and production by canine smooth muscle cells.- 16 Degeneration of human cerebrovascular smooth muscle cells and pericytes caused by amyloid ? protein.- 17 Vasoactivity of amyloid ? peptides.- 18 CAA in transgenic mouse models of Alzheimer’s disease. What can we learn from APP transgenic mouse models?.- 19 Cerebral amyloid angiopathy in aged dogs and nonhuman primates.- 20 Vascular transport of Alzheimer’s amyloid ? peptides and apolipoproteins.