E-Book, Englisch, Band 15, 368 Seiten
Wagner Robustness and Evolvability in Living Systems
Course Book
ISBN: 978-1-4008-4938-3
Verlag: De Gruyter
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, Band 15, 368 Seiten
Reihe: Princeton Studies in Complexity
ISBN: 978-1-4008-4938-3
Verlag: De Gruyter
Format: PDF
Kopierschutz: 1 - PDF Watermark
No detailed description available for "Robustness and Evolvability in Living Systems".
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
List of Figures ix
Acknowledgments xiii
Chapter 1: Introduction 1
PART I: ROBUSTNESS BELOW THE GENE LEVEL 13
Chapter 2: The Genetic Alphabet 15
Chapter 3: The Genetic Code 25
Chapter 4: RNA Structure 39
Chapter 5: Proteins and Point Mutations 62
Chapter 6: Proteins and Recombination 78
PART II: ROBUSTNESS ABOVE THE GENE LEVEL 91
Chapter 7: Regulatory DNA Regions and Their Reorganization in Evolution 93
Chapter 8: Metabolic Pathways 104
Chapter 9: Metabolic Networks 120
Chapter 10: Drosophila Segmentation and Other Gene Regulatory Networks 143
Chapter 11: Phenotypic Traits, Cryptic Variation, and Human Diseases 161
Chapter 12: The Many Ways of Building the Same Body 175
PART III: COMMON PRINCIPLES 193
Chapter 13: Neutral Spaces 195
Chapter 14: Evolvability and Neutral Mutations 217
Chapter 15: Redundancy of Parts or Distributed Robustness? 228
Chapter 16: Robustness as an Evolved Adaptation to Mutations 247
Chapter 17: Robustness as an Evolved Adaptation to Environmental Change and Noise 270
Chapter 18: Robustness and Fragility: Advantages to Variation and Trade-offs 281
PART IV: ROBUSTNESS BEYOND THE ORGANISM 295
Chapter 19: Robustness in Natural Systems and Self-Organization 297
Chapter 20: Robustness in Man-made Systems 310
Epilogue: Seven Open Questions for Systems Biology 321
Bibliography 323
Index 359
