Walters Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation

A Practical Guide to Analysis and Interpretation
1. Auflage 2009
ISBN: 978-0-470-87191-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 380 Seiten, E-Book

Reihe: Statistics in Practice

An essential, up-to-date guide to the design of studies andselection of the correct QoL instruments for observational studiesand clinical trials.
Quality of Life (QoL) outcomes or Person/Patient ReportedOutcome Measures (PROMs) are now frequently being used inrandomised controlled trials (RCTs) and observational studies. Thisbook provides a practical guide to the design, analysis andinterpretation of studies that use such outcomes.
QoL outcomes tend to generate data with discrete, bounded andskewed distributions. Many investigators are concerned about theappropriateness of using standard statistical methods to analyseQoL data and want guidance on what methods to use. QoL outcomes arefrequently used in cross-sectional surveys and non-randomisedhealth-care evaluations.
* Provides a user-friendly guide to the design and analysis ofclinical trials and observational studies in relation to QoLoutcomes.
* Discusses the problems caused by QoL outcomes and presentsintervention options to help tackle them.
* Guides the reader step-by-step through the selection ofappropriate QoLs.
* Features exercises and solutions and a supporting websiteproviding downloadable data files.
Illustrated throughout with examples and case studies drawn fromthe author's experience, this book offers statisticians andclinicians guidance on choosing between the numerous available QoLinstruments.

Autoren/Hrsg.

Walters, Stephen J.

Über Autor(innen)

Stephen J. Walters - School of Health and Related Research, University of Sheffield. Dr Walters has had experience both in research and teaching, and is currently the Senior Lecturer in Medical Statistics at Sheffield University. He has conducted numerous grant-funded research projects, and has nearly 150 publications to his name. These include 85 articles in a range of refereed journals, 2 co-authored books, and contributed chapters in three other books.