Weatherley Engineering Processes for Bioseparations

1. Auflage 2013
ISBN: 978-1-4832-9210-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 250 Seiten, Web PDF

The use of biotechnology in chemical synthesis offers up numerous advantages to the engineer in the process industries, but it also presents a number of fundamental challenges and difficulties which impinge directly on separation process requirements. The use of biochemical separations has grown significantly during the past decade, and is especially used in process industries such as healthcare and food processing. However it is becoming increasingly more important in areas such as recycling and waste-water treatment and as industry shifts towards cleaner processes biochemical separations will continue to grow. The two main objectives of this book are to focus on the application of existing separation process techniques to the recovery and purification of biologically derived products and to examine the state of knowledge of new techniques which have future potential. Within these objectives the complexities and breadth of problems associated with biological separations are discussed, specific engineering techniques are featured and their adaptation to biochemical separations are highlighted.

Autoren/Hrsg.

Weatherley, Laurence R.

Inhaltsverzeichnis

1;Front Cover;1
2;Engineering Processes for Bioseparations;4
3;Copyright Page;5
4;Table of Contents;6
5;Contributors;8
6;Chapter 1. Introduction;10
7;Chapter 2. Introduction to downstream processing;14
7.1;2.1 Introduction;14
7.2;2.2 Advantages of biological processes;14
7.3;2.3 Basic features of biochemical systems;15
7.4;2.4 Categories of biological products;18
7.5;2.5 Economic aspects of downstream processing;19
7.6;2.6 Interaction between fermentation processes and downstream processing;23
7.7;2.7 Principal features of downstream processes;25
7.8;2.8 Selection criteria for downstream processes;29
7.9;2.9 Downstream process unit operations;34
7.10;2.10 Modelling of downstream processes;37
7.11;2.11 Summary and conclusions;41
7.12;References;42
8;Chapter 3. Molecular recognition;44
8.1;3.1 Introduction;44
8.2;3.2 Binding forces involved in molecular recognition;46
8.3;3.3 Molecular recognition by synthetic hosts;48
8.4;3.4 Molecular recognition in biological systems;68
8.5;3.5 Use of molecular recognition in drug design;73
8.6;3.6 Separation processes based on molecular recognition;74
8.7;3.7 Future applications of molecular recognition;76
8.8;References;77
9;Chapter 4. Protein precipitation;82
9.1;4.1 Introduction;82
9.2;4.2 Protein solubility;85
9.3;4.3 Protein precipitation methods;88
9.4;4.4 The precipitate particle;105
9.5;4.5 Process considerations;107
9.6;4.6 Future prospects;112
9.7;Acknowledgements;112
9.8;References;113
10;Chapter 5. Solid-liquid separation;119
10.1;5.1 Introduction;119
10.2;5.2 Pretreatment of suspensions;123
10.3;5.3 Equipment and principles;125
10.4;References;143
10.5;Bibliography;143
11;Chapter 6. Membrane separation processes;144
11.1;6.1 Background;144
11.2;6.2 Membrane materials and applications;146
11.3;6.3 Selectivity;149
11.4;6.4 Membrane configurations;155
11.5;6.5 Membrane applications;158
11.6;References;173
11.7;Bibliography;174
12;Chapter 7. Solvent extraction processes for biological products;175
12.1;7.1 Introduction;175
12.2;7.2 Mass transfer fundamentals;178
12.3;7.3 Solvent extraction processes;179
12.4;7.4 Related processes based on solvent extraction;186
12.5;7.5 Solvent selection criteria;188
12.6;7.6 Mass transfer with biological systems;192
12.7;7.7 Phase separation with biological systems;194
12.8;7.8 Equipment options and selection;197
12.9;7.9 Summary and conclusions;204
12.10;7.10 Symbols;205
12.11;References;206
12.12;Appendix A.1 Physical extraction;208
12.13;A.2 Ion pair extraction;210
13;Chapter 8. Aqueous two-phase extraction systems;211
13.1;8.1 Introduction;211
13.2;8.2 Aqueous two-phase systems;213
13.3;8.3 Equipment and scale-up;225
13.4;8.4 Processes;231
13.5;References;239
14;Chapter 9. Near-critical fluid extraction for biological and food products;242
14.1;9.1 Introduction;242
14.2;9.2 Basic principles;243
14.3;9.3 Recent developments and applications;249
14.4;References;265
15;Chapter 10. Electrokinetic separation processes for biochemical products;267
15.1;10.1 Introduction;267
15.2;10.2 Theoretical background;268
15.3;10.3 Applications;273
15.4;10.4 Other electrokinetic processes;283
15.5;10.5 Conclusions;289
15.6;10.6 Symbols;290
15.7;10.7 Acknowledgement;291
15.8;References;291
16;Index;294