Buch, Englisch, Band 13, 436 Seiten, HC gerader Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 7981 g
Buch, Englisch, Band 13, 436 Seiten, HC gerader Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 7981 g
Reihe: Advances in Biochemistry in Health and Disease
ISBN: 978-3-319-17436-5
Verlag: Springer International Publishing
The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes. Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone. The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
Weitere Infos & Material
1. Fibrosis and Heart Failure - Cause or Effect?.- 2. Fibroblast Activation in the Infarcted Myocardium.- 3. Mechanical and Matrix Regulation of Valvular Fibrosis.- 4. Bone Marrow-Derived Progenitor Cells, micro-RNA and Fibrosis.- 5. The Stressful Life of Cardiac Myofibroblasts.- 6. Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies Aldosteronism.- 7. Embryological origin of valve progenitor cells.- 8. Diverse cellular origins of cardiac fibroblasts.- 9. Non-Canonical Regulation of TGF-ß1 Signaling: A Role for Ski/Sno and YAP/TAZ.- 10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart.- 11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis.- 12. Remodelling of the cardiac extracellular matrix: Role of collagen degradation and accumulation in pathogenesis of heart failure.- 13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix Remodelling.- 14. Collagen processing and its role in Fibrosis.- 15. Mechanisms of Cardiac Fibrosis.- 16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and Myocytes.- 17. Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives.- 18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure.- 19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart.- 20. Cardiac Tissue Engineering for the Treatment of Heart Failure Post-Infarction.- 21. Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves.