Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Principles and Applications
Erscheinungsjahr 2021
ISBN: 978-0-444-59432-7
Verlag: Elsevier Science & Technology

Buch, Englisch, 484 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 1000 g

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.

Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.

Zielgruppe

<p>researchers in analytical chemistry, biology and engineering, researchers enrolled in a lab-on-chip, microfluidics, or biomedical devices course or engaged in research related fields.</p> <p>researchers in medical instrumentation, health sciences, biotechnology, pharmaceuticals, and engineering professionals and industries wishing an overview of the microfluidics and life sciences microsystems fields.</p>

Autoren/Hrsg.

Yang, Chaoyong

Li, Paul C. H.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie
• Naturwissenschaften Chemie Analytische Chemie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Maschinenbau Mechatronik, Mikrosysteme (MEMS), Nanosysteme
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Strömungslehre

Inhaltsverzeichnis

Part I: Fundamentals of microfluidic/nanofluidic lab-on-a-chip1. Micromachining Methods2. Micromachining of silicon, glass devices3. Micromachining of polymers4. Fabrication of paper-based microfluidic devices5. Biocompatibility and surface modifications6. Systems interconnect and world-to-chip interface7. Microfluidic Flow control

Part II: New Emerging Techniques8. Droplet microfluidics9. Closed-channel Droplet generation10. Open-format Digital microfluidics11. Nanofluidics12. Nanofabrication13. Characteristics of nanofluidics

Part III: Applications14. Applications to Cell Biology15. Manipulation of cells 16. Cellular measurements and analysis17. Single-cell analysis18. 3D cell culture19. Organs-on-a-chip20. Applications to Nuclei Aids Analysis21. Nucleic acids extraction and purification22. Nucleic acids amplification23. Forensic DNA typing24. Microarray DNA chips25. Applications to proteins analysis26. Immunoassay27. Protein separation28. Enzymatic analysis29. Proteomics30. Applications to global health31. Low-cost Paper-based diagnosis devices32. Field diagnosis33. Other applications43. Environmental analysis44. Forensic analysis45. Small ions and molecules analysis46. Microreacter47. Perspective48. Instrument/device commercialization

Über Autor(innen)

Yang, Chaoyong
Dr. Chaoyong Yang received his PhD from University of Florida in 2006 under the guidance of Professor Weihong Tan. He joined Professor Richard Mathies' group at the University of California, Berkeley as a postdoc. In 2008, he joined Xiamen University where he is now a Distinguished Professor in the Department of Chemical Biology. Professor Yang has published over 200 articles in international journals which have received over 11 000 citations, and is named inventor on over 40 patents. He serves as associate editor for ACS Applied Bio Materials. He is a Fellow of the Royal Society of Chemistry. He is the recipient of CAPA Distinguished Faculty Award in 2012, National Outstanding Young Investigator Award in 2013, Chinese Young Analyst Award in 2015, Chinese Chemical Society-Royal Society of Chemistry Young Chemist Award in 2016, and 2021 ACS Advances in Measurement Science Lectureship Award. His current research is particularly focused on bio-sensing, high throughput evolution, single cell analysis and microfluidics.

Li, Paul C. H.
Dr. Paul Li obtained his Ph.D. in analytical chemistry at the University of Toronto, and conducted postdoctoral work at the University of Alberta. Then, he developed the microfluidic lab-on-a-chip at Simon Fraser University, where he was promoted to full professor. Dr. Li is interested in integrating chip microfluidics for chemical sensing, single-cell analysis, and nucleic acid bioassay. He has been visiting professors at Johannes Gutenberg Universitat-Mainz (Germany), Griffith University (Australia) and City University of Hong Kong. Dr. Li has published several books, e.g. Fundamentals of lab on a chip for biological analysis and discovery, and Microarray Technology: Methods and Applications. He is associate editor of Canadian Journal of Pure and Applied Sciences, and sits on the editorial board of Hong Kong Pharmaceutical Journal. Dr. Li is the inventor of six patented technologies and 5 pending patents, and he is the founder of ZellChip Technologies Inc. specializing in microfluidics-based instruments and solutions.