Fluorescent Probes for Bioactive Species

Design, Synthesis, and Biomedical Applications
1. Auflage 2026
ISBN: 978-3-527-35466-5
Verlag: Wiley-VCH GmbH

Buch, Englisch, 384 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 666 g

Comprehensive introduction to the design principles, response mechanisms, and imaging applications of organic small-molecule fluorescence probes

Fluorescent Probes for Bioactive Species provides a systematic primer for organic small-molecule fluorescence probes. The book starts by discussing the principles of molecular recognition, the phenomenon of fluorescence luminescence, and fluorescent probes design. Each chapter of the book is separated based on the classification of biologically active species. Instead of gathering all of the related fluorescent probes for a typical analyte, the book mainly focuses on the representative probes that present new recognition mechanisms and the related optimization theories to realize better detection and imaging.

In each chapter, the relationship and differences between the complex biomolecules of the species are discussed. The corresponding pros and cons of the recognition mechanisms based on these structural or reactive differences create the core of each section’s discussion. Finally, the specifics of biological sample-oriented design and development of fluorescent probes are discussed.

Fluorescent Probes for Bioactive Species includes information on:

- Excitation modes of fluorescent probes, fluorescence reporting modes, and optical modulation mechanisms of fluorescent probes
- Fluorescent probes of hydrogen peroxide (H2O2), hypochlorous acid (HCiO), hydroxyl radical (OH), superoxide anion (O&ndash2), and singlet oxygen (1O2)
- Synthesis, recognition mechanism, and bioimaging of norepinephrine probes, dopamine probes, acetylcholine probes, glutamic acid, 5-hydroxytryptamine, and histamine
- Active molecules and enzymes of dual-responsive fluorescent probes
- Biological functions of reactive sulfur species (RSS)

Fluorescent Probes for Bioactive Species is an essential, up-to-date reference for chemists, scientists, and professionals in the sensor industry seeking to promote the development of new tools for biomonitoring and develop a deep understanding of mysterious biological events.

Autoren/Hrsg.

Yin, Caixia

Fachgebiete

• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Analytische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

1 FLUORESCENCE AND MOLECULAR RECOGNITION
1.1 Advancing fluorescence theory
1.2 Advancing fluorescent dyes
1.3 Fluorescent probes for molecular recognition
 
2 FLUORESCENT PROBES
2.1 Excitation modes of fluorescent probes
2.2 Fluorescence reporting mode
2.3 Optical modulation mechanism of fluorescent probes
2.4 The reaction mechanism of small molecule fluorescent probes
 
3 FLUORESCENCE PROBE OF REACTIVE OXYGEN SPECIES (ROS)
3.1 Fluorescence probe of hydrogen peroxide (H2O2)
3.2 Fluorescence probe of hypochlorous acid (HClO)
3.3 Fluorescence probe of hydroxyl radical (·OH)
3.4 Fluorescence probe of superoxide anion(O2?-)
3.5 Fluorescence probe of Singlet oxygen (1O2)
 
4 FLUORESCENCE PROBE OF REACTIVE SULFUR SPECIES (RSS)
4.1 Introduction to biological functions of RSS
4.2 Synthesis, recognition mechanism, and biomedical applications of Cys probes
4.3 Synthesis, recognition mechanism and application of Hcy probes
4.4 Synthesis,recognition mechansim and biomaging of GSH probes
4.5 Synthesis,recognition mechansim and biomaging of H2S probes
4.6 Synthesis,recognition mechansim and biomaging of SO2 probes
4.7 Synthesis, recognition mechansim and biomaging of polysulfide probes
 
5 FLUORESCENT PROBES FOR REACTIVE NITROGEN SPECIES
5.1 Introduction to biological functions of RNS
5.2 Synthesis, recognition mechanism and bioapplication of NO probes
5.3 Synthesis, recognition mechanism and bioapplication of ONOO- probes
5.4 Synthesis, recognition mechanism and bioapplication of HNO
 
6 FLUORESCENT PROBES FOR REACTIVE CARBON SPECIES
6.1 Introduction to biological functions of RCS
6.2 Synthesis, recognition mechanism, and bioimaging of carbon monoxide probes
6.3 Synthesis, recognition mechanism, and bioapplication of formaldehyde
6.4 Synthesis, recognition mechanism, and bioapplication of ethylene
6.5 Synthesis, recognition mechanism, and bioimaging of malonaldehyde probes
 
7 FLUORESCENT PROBES FOR OXIDOREDUCTASE ENZYMES
7.1 Brief introduction of enzymes in redox modulation
7.2 Synthesis, recognition mechanism and application of monoamine probes
7.3 Synthesis, recognition mechanism and application of NAD(P)H: quinine oxidoreductase probes
7.4. Synthesis, recognition mechanism and application of Nitroreductase probes
7.5 Synthesis, recognition mechanism and application of tyrosinase probes
7.6 Synthesis, recognition mechanism and application of thioredoxin reductase probes
 
8 FLUORESCENT PROBES FOR NEUROTRANSMITTERS
8.1 Biological function of neurotransmitter
8.2 Synthesis, recognition mechanism, and bioimaging of norepinephrine probes
8.3 Synthesis, recognition mechanism, and bioimaging of dopamine probes
8.4 Synthesis, recognition mechanism, and bioimaging of acetylcholine probes
8.5 Synthesis, recognition mechanism, and bioimaging of glutamic acid
8.6 Synthesis, recognition mechanism, and bioimaging of 5-hydroxytryptamine
8.7 Synthesis, recognition mechanism, and bioimaging of histamine
8.8 Other neurotransmitters
 
9 DUAL-RESPONSE FLUORESCENT PROBES FOR THE ABOVE REACTIVE SPECIES
9.1 Synthesis, recognition mechanism, and biological imaging of RSS dual responsive fluorescent probes
9.2 Synthesis, recognition mechanism and bioimaging of ROS double-response fluorescent probes
9.3 Synthesis, recognition mechanism, and biological imaging of RSS and ROS dual responsive fluorescent probes
9.4 Synthesis, recognition mechanism, and bioimaging of dual-responsive fluorescent probes for RSS and RNS
9.5 Synthesis, recognition mechanism, and bioimaging of active molecule and enzyme dual-responsive fluorescent probes
9.6 Synthesis, recognition mechanism, and bioimaging of active species with ATP-dual-responsive fluorescent probes
 
10 OTHER BIOACTIVE SPECIES FLUORESCENT PROBES
10.1 Synthesis, recognition mechanism, and bioimaging of NAD(P)H
10.2 Synthesis, recognition mechanism and bioimaging of pyruvic acid probes
10.3 Synthesis, recognition mechanism and bioimaging of Lactic acid probes
10.4 Synthesis, recognition mechanism, and bioimaging of lipid peroxidation probes
10.5 Synthesis, recognition mechanism, and bioimaging of ATP
 
11 SUMMARY

Über Autor(innen)

Professor Caixia Yin is a Director of the Key Laboratory of Chemical Biology and Molecular Engineering at the Ministry of Education and Institute of Molecular Science, Shanxi University, China. She received the Outstanding Young Scholar award from the National Natural Science Foundation of China for and was selected as the 2022 Elsevier China Highly Cited Scholar, the 2022 the World's Top 2% Top Scientists (Lifetime Lists), and the 2020 Chinese Chemical Letters Outstanding Young Scholar.