Hypoxic Pulmonary Vasoconstriction

Cellular and Molecular Mechanisms
Softcover Nachdruck of the original 1. Auflage 2004
ISBN: 978-1-4757-7992-9
Verlag: Springer US

Buch, Englisch, Band 252, 590 Seiten, Paperback, Format (B × H): 152 mm x 229 mm, Gewicht: 873 g

Reihe: Developments in Cardiovascular Medicine

Complete reference on hypoxic pulmonary vasoconstriction and hypoxia-mediated pulmonary hypertension.

Can be utilized by the physician-scientist and researcher in the laboratory as both a technical manual and reference.

Designed for clinicians to guide and improve clinical treatment and diagnosis of patients with hypoxia mediated pulmonary vascular disease and right heart failure.

Zielgruppe

Research

Autoren/Hrsg.

Yuan, Jason X. -J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete AINS Intensivmedizin

Inhaltsverzeichnis

Physiology and Pathophysiology of Hypoxic Pulmonary Vasoconstriction.- Physiological Function of Hypoxic Pulmonary Vasoconstriction.- Hypoxic Pulmonary Vasoconstriction: Heterogeneity.- The Physics of Hypoxic Pulmonary Hypertension and Its Connection with Gene Actions.- Role of Intra Cellular Ca2+ and Ca2+ Sensitivity in Hypoxic Pulmonary Vasoconstriction.- Ca2+ Sparks in Pulmonary Artery Smooth Muscle Cells: Implications for Hypoxic Pulmonary Vasoconstriction.- Hypoxia-Mediated Regulation of Ca2+ Transients in Pulmonary Artery Smooth Muscle Cells.- Calcium Mobilization by Hypoxia in Pulmonary Artery Smooth Muscle.- Critical Role of Ca+ Sensitization in Acute Hypoxic Pulmonary Vasoconstriction.- Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction.- Regulation of Ion Channels in Pulmonary Artery Smooth Muscle Cells.- Regulation of O2-Sensitive K+ Channels by a Mitochondrial Redox Sensor: Implications for Hypoxic Pulmonary Vasoconstriction.- Hypoxic Regulation of K+ Channel Expression and Function in Pulmonary Artery Smooth Muscle Cells.- Transient Receptor Potential Channels and Capacitative Ca2+ Entry in Hypoxic Pulmonary Vasoconstriction.- Role of Endothelium in Hypoxic Pulmonary Vasoconstriction.- Endothelium-dependent Hypoxic Pulmonary Vasoconstriction.- Mechanisms of Oxygen Sensing in the Pulmonary Vasculature.- Chemistry of Oxygen and Its Derivatives in the Lung.- Interaction of Oxidants With Pulmonary Vascular Signaling Systems.- Mitochondrial Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction.- Redox Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction.- Mitochondrial Diversity in the Vasculature: Implications for Vascular Oxygen Sensing.- Hypoxia, Cell Metabolism, and cADPR Accumulation.- Oxygen-Sensing Mechanisms in Other Organs and Tissues.- Involvement of Intracellular Reactive Oxygen Species in the Control of Gene Expression by Oxygen.- Oxygen Sensing, Oxygen-sensitive Ion Channels and Mitochondrial Function in Arterial Chemoreceptors.- Oxygen Sensing by Adrenomedullary Chromaffin Cells.- Oxygen-sensitive Ion Channels in Pheochromocytoma (PC12) Cells.- Pathology and Mechanisms of Hypoxia-Induced Pulmonary Hypertension.- Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension.- Rho/Rho-kinase Signaling in Hypoxic Pulmonary Hypertension.- Hypoxia-sensitive Transcription Factors and Growth Factors.- Heterogeneity in Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation.- Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Treatment.- Roles for Vasoconstriction and Gene Expression in Hypoxia-induced Pulmonary Vascular Remodeling.- Polyamine Regulation in Hypoxic Pulmonary Arterial Cells.- Strain Differences of Hypoxia-Induced Pulmonary Hypertension.- Experimental Models for the Study of Hypoxic Pulmonary Vasoconstriction.- Animal and In Vitro Models for Studying Hypoxic Pulmonary Vasoconstriction.- Transgenic and Gene-Targeted Mouse Models in Hypoxic Pulmonary Hypertension Research.- Measurement of Ionic Currents and Intracellular Ca2+ Using Patch Clamp and Fluorescence Microscopy Techniques.