Advances in Immunology

1. Auflage 2002
ISBN: 978-0-08-054405-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 80, 320 Seiten, Web PDF

Reihe: Advances in Immunology

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles in this volume address topics such as protein degradation and the generation of MHC class I-presented peptides, proteolysis and antigen presentation by MHC Class II molecules, cytokine memory of T-helper lymphocytes, Ig gene hypermutation, generalization of single immunological experiences by idiotypically mediated clonal connections, and aging of the immune system. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Autoren/Hrsg.

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Contributors;10
4;Chapter 1. Protein Degradation and the Generation of MHC Class I-Presented Peptides;12
4.1;I. Introduction;12
4.2;II. Protein Degradation;13
4.3;III. Antigen Presentation;32
4.4;IV. Conclusion;62
4.5;References;63
5;Chapter 2. Proteolysis and Antigen Presentation by MHC Class II Molecules;82
5.1;I. Introduction;82
5.2;II. Protease Activity in Antigen-Presenting Cells;84
5.3;III. Proteolytic Digestion of Ii;98
5.4;IV. Proteolytic Control of Vesicle Biogenesis and Class II Trafficking through the Endocytic Pathway;103
5.5;V. The Role of Ii in Regulating the Proteolytic Activities of APCs;105
5.6;VI. Antigen Processing;107
5.7;VII. Concluding Remarks;113
5.8;References;114
6;Chapter 3. Cytokine Memore of T Helper Lymphocytes;126
6.1;I. Introduction;126
6.2;II. Cytokine Signals in the Induction of T Cell Cytokine Memore;128
6.3;III. Key Transcription Factors in the Induction and Maintenance of Cytokine Memory;133
6.4;IV. Role of the Antigen-Presenting Cell in the Induction of Cytokine Memory;141
6.5;V. T Cell Receptor Signals in the Induction of Cytokine Memory;144
6.6;VI. Epigenetic Modifications of Cytokine Genes ;149
6.7;VII. Stability and Plasticity of Cytokine Memory;156
6.8;VIII. Cytokine Memory as Part of T Cell Differentiation Programs;160
6.9;IX. Cytokine Memory of Memory T Cells;165
6.10;References;169
7;Chapter 4. Ig Gene Hypermutation: A Mechanism Is Due;194
7.1;I. Introduction;194
7.2;II. Mismatch Repair;194
7.3;III. The NickaseŽ;197
7.4;IV. The Role of Transcription;198
7.5;V. Hypermutation Is Generated by a DNA Polymerase;199
7.6;VI. Error-Prone DNA Polymerases;202
7.7;VII. More DNA Polymerases;205
7.8;VIII. Targeting to Non-Ig Genes;206
7.9;IX. AID;206
7.10;X. Conclusion;207
7.11;References;208
8;Chapter 5. Generalization of Single Immunological Experiences by ldiotypically Mediated Clonal Connections;214
8.1;I. Introduction;214
8.2;II. Idotypic Transformation of Single Immunological Experiences in the Adult;215
8.3;III. Transfer of Maternal Immunological Experience to the Offspring;234
8.4;IV . Conclusion;239
8.5;References;240
9;Chapter 6. The Aging of the Immune System;254
9.1;I. The Biological Aging Process;254
9.2;II. The Aging of the Immune System ;259
9.3;III. The Consequences of Immune Senescence;274
9.4;IV. Modes of lntervention;279
9.5;V. Conclusion;282
9.6;References;284
10;Index;296