Buch, Englisch, 688 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 1466 g
ISBN: 978-1-118-93042-7
Verlag: Wiley
Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals.
A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.
Autoren/Hrsg.
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Weitere Infos & Material
Contributors xxiv
Preface xxxi
Part I Introduction 1
1 Novel Omics Technologies in Food Nutrition 3
Xuewu Zhang, Lijun You, Wei Wang, and Kaijun Xiao
1.1 Introduction 3
1.2 Transcriptomics in Nutritional Research 4
1.3 Proteomics in Nutritional Research 5
1.4 Metabolomics in Nutritional Research 7
1.5 Systems Biology in Nutritional Research 9
1.6 Conclusions 9
References 10
2 Seafood Authentication using Foodomics: Proteomics, Metabolomics, and Genomics 14
Karola Böhme, Jorge Barros-Velázquez, Pilar Calo-Mata, José M. Gallardo, and Ignacio Ortea
2.1 Introduction 14
2.2 Proteomic Approaches 15
2.3 Metabolomic Approaches 19
2.4 Genomic Approaches 20
2.5 Conclusions 25
References 26
3 A Foodomics Approach Reveals Hypocholesterolemic Activity of Red Microalgae 31
Irit Dvir, Aliza H. Stark, and Shoshana (Malis) Arad
3.1 Introduction 31
3.2 Marine Functional Foods and Supplements 32
3.2.1 Algae as a Functional Food 32
3.2.2 The Nutritional Value of Algae 32
3.3 Microalgae 33
3.3.1 Red Microalgae 34
3.3.2 Sulfated Polysaccharides from Red Microalgae 34
3.3.3 Red Microalgae as a Hypocholesterolemic Agent 35
3.4 Summary 37
References 37
Part II Genomics 41
4 Gene-Diet Interaction and Weight Management 43
Lu Qi
4.1 Introduction 43
4.2 Diet and Lifestyle Modifications in Weight Management 44
4.3 The Role of Genetic Factors in Determining Body Weight and Weight Loss 44
4.4 Gene-Diet Interactions on Body Weight and Risk of Obesity 46
4.5 Gene-Diet Interactions on Weight Loss in Randomized Clinical Trials 47
4.6 Gene-Diet Interactions on Weight Maintenance 48
4.7 Personalized Weight Management through Diet and Lifestyle Modifications 49
4.8 Summary and Concluding Remarks 50
Acknowledgments 50
References 50
5 NutrimiRomics: The Promise of a New Discipline in Nutrigenomics 53
Amitava Das and Chandan K. Sen
5.1 Introduction 53
5.2 miRomics: A New Cornerstone 56
5.3 Nutrigenomics and miR 57
References 58
6 Genomics as a Tool to Characterize Anti-inflammatory Nutraceuticals 61
Amitava Das, Scott Chaffee, and Sashwati Roy
6.1 Chronic Inflammation in Disease 61
6.1.1 Vascular Disorders 61
6.1.2 Respiratory Disorders 62
6.1.3 Gastrointestinal Tract 62
6.1.4 Neurodegenerative Diseases 63
6.1.5 Cancer 63
6.1.6 Rheumatic Diseases 63
6.2 Nutraceuticals in the Management of Chronic Inflammation 64
6.3 GeneChip TM as a Tool to Characterize the Anti-Inflammatory Properties of Nutraceuticals 65
References 68
7 Nutrigenomics, Inflammaging, and Osteoarthritis: A Review 71
Ali Mobasheri, Richard Barrett-Jolley, Caroline A. Staunton, Chris Ford, and Yves Henrotin
7.1 Introduction 71
7.2 Osteoarthritis (OA) 72
7.3 Antioxidants and the Inflammatory Microenvironment 73
7.4 Inflammaging 75
7.5 Nutrigenomics 76
7.6 Muscle Inflammation in OA 77
7.7 Conclusions 80
Acknowledgments, Competing Interests, and Disclosures 80
References 80
8 Genetic Basis of Anti-Inflammatory Properties of Boswellia Extracts 85
Golakoti Trimurtulu, Chandan K. Sen, Alluri V. Krishnaraju, Kiran Bhupathiraju, and Krishanu Sengupta
8.1 Introduction 85
8.2 Boswellia serrata 86
8.3 Mechanism of Action 87
8.4 Development of 5-LOXIN ® (BE-30) 87
8.4.1 Genetic Basis for Efficacy of 5-LOXIN ® (BE-30) 88
8.5 Gene Chip Probe Array Analysis 88
8.6 Proteomics 89
8.7 Molecular Basis of Anti-Inflammatory Properties of 5-LOXIN ® 95
8.8 In vivo Studies 96
8.9 Safety of 5-LOXIN ® 96
8.10 Clinical Efficacy of 5-LOXIN ® in the Management of Osteoarthritis 97
8.11 An Advanced 5-LOXIN ®: Aflapin ® 99
8.12 Conclusion 100
References 100
9 Cancer Chemopreventive Phytochemicals Targeting NF- B and Nrf2 Signaling Pathways 102
Hye-Kyung Na and Young-Joon Surh
9.1 Introduction 102
9.2 Molecular-Based Cancer Chemoprevention 104
9.3 Nuclear Factor-Kappa B (NF- B) 105
9.3.1 Curcumin 106
9.3.2 [6]-Gingerol 107
9.3.3 Capsaicin 107
9.3.4 Resveratrol 107
9.3.5 Quercetin 108
9.3.6 Sulforaphane 108
9.3.7 Genistein 108
9.4 Nrf2 108
9.4.1 Sulforaphane 109
9.4.2 Curcuminoids 111
9.4.3 Egcg 111
9.4.4 Allyl Sulfides 111
9.4.5 Resveratrol 112
9.4.6 Pungent Vanilloids 112
9.4.7 Lycopene 112
9.4.8 Coffee-Derived Diterpenes 113
9.4.9 Carnosol 113
9.4.10 Xanthohumol 113
9.4.11 Zerumbone 113
9.4.12 Chalcones 114
9.5 Interplay/Crosstalk between Nrf2 and NF- B Signaling Pathways 114
9.6 Conclusion 115
Acknowledgment 116
References 116
10 The Beneficial Health Effects of Fucoxanthin 122
Kazuo Miyashita and Masashi Hosokawa
10.1 Introduction 122
10.2 The Beneficial Health Effects of Carotenoids as Antioxidants 124
10.3 Anticancer Activity of Fucoxanthin 124
10.4 Anti-Obesity Effects of Fucoxanthin 126
10.5 Anti-Diabetic Effects of Fucoxanthin 127
10.6 Conclusion 130
References 131
11 Nutrition, Genomics, and Human Health: A Complex Mechanism for Wellness 135
Okezie I. Aruoma
11.1 Introduction 135
11.2 Nutrition Sciences and Clinical Applications in Nutritional Genomics 136
References 139
12 Application of Genomics and Bioinformatics Analysis in Exploratory Study of Functional Foods 140
Kohsuke Hayamizu and Aiko Manji
12.1 Introduction 140
12.2 Analysis Tools 141
12.2.1 GeneSpring GX 141
12.2.2 Bioconductor 141
12.2.3 Others 141
12.3 Interpretation Tools 142
12.3.1 Go Analysis Tools 142
12.3.2 Pathway Analysis Tools 142
12.3.3 Association Network Analysis Tools 143
12.4 Application Example of Kale (Brassica oleracea L. Var Acephala DC) 143
12.4.1 Animal Study and DNA Microarray Analysis 144
12.4.2 Data Analysis 144
12.4.3 Result 146
12.5 Conclusion 148
References 149
13 Omics Analysis and Databases for Plant Science 150
Masaaki Kobayashi, Hajime Ohyanagi, and Kentaro Yano
13.1 Introduction 150
13.2 NGS Technologies and Data Processing 151
13.3 De novo Plant Genome Assembly by NGS 151
13.3.1 Basics of Plant Genome Assembly 151
13.3.2 Plant Genome Assembly by NGS Short Reads 152
13.3.3 Hybrid-Type Assembly 152
13.4 Plant Genome Resequencing by NGS 153
13.4.1 Conventional Resequencing Technologies 153
13.4.2 GBS/RAD-Seq 154
13.5 Plant Transcriptome Analysis by NGS 154
13.5.1 Transcriptome Analysis with Reference Genome Sequences 154
13.5.2 Reference-Free Transcriptome Analysis 154
13.6 Plant Genome and Annotation Databases 154
13.6.1 TAIR (Arabidopsis) 154
13.6.2 RAP-DB (Rice) 155
13.6.3 Other Plants 155
13.7 Plant Omics Databases 155
13.7.1 Transcriptome Databases 155
13.7.2 Gene Expression Network Databases 156
13.7.3 Metabolic Pathway Databases 156
13.7.4 Other Databases for Omics Integration 156
13.8 Conclusion 156
References 157
14 Synergistic Plant Genomics and Molecular Breeding Approaches for Ensuring Food Security 160
Shouvik Das and Swarup K. Parida
14.1 Introduction 160
14.2 Plant Genomics, Transcriptomics, Proteomics, and Metabolomics Resources 161
14.3 Molecular Markers in Plant Genome Analysis 163
14.3.1 Microsatellite Markers 164
14.3.2 Single Nucleotide Polymorphism (SNP) Markers 166
14.4 Identification of Functionally Relevant Molecular Tags Governing Agronomic Traits 167
14.4.1 Plant Genetic Resources Rich in Trait Diversity 167
14.4.2 High-Throughput Phenotyping 168
14.4.3 High-Throughput Marker Genotyping 168
14.4.4 Identification and Mapping of QTLs/Genes 168
14.4.5 Trait Association Mapping 170
14.5 Genomics-Assisted Crop Improvement 170
References 175
15 Combinatorial Approaches Utilizing Nutraceuticals in Cancer Chemoprevention and Therapy: A Complementary Shift with Promising Acuity 185
Madhulika Singh and Yogeshwer Shukla
15.1 Introduction 185
15.2 Nutraceuticals 187
15.3 Nutraceuticals and Key Events in Cancer Development 189
15.3.1 Inflammation 189
15.3.2 Oxidative Stress 189
15.3.3 Antiproliferation 190
15.3.4 Cell-Cycle Arrest 190
15.3.5 Apoptosis 190
15.3.6 Transforming Growth Factor-ß (TGF-ß)/Smad Signaling Pathway 191
15.3.7 ß-Catenin 191
15.4 Nutraceuticals in Combinatorial Therapy of Human Cancer: A Pledge of the Future 191
15.4.1 Nutraceuticals in Cruciferous Vegetables: Potential for Combination Therapy 191
15.4.2 Indole-3-Carbinol (I3C) and Combinations 192
15.4.3 Phenethylisothiocyanate (PEITC) and Combinations 192
15.4.4 Sulforaphane (SFN) and Combinations 193
15.4.5 Synergism among Cruciferous Compounds 194
15.4.6 Combinations of Cruciferous Compounds with Conventional Cancer Chemotherapeutics 194
15.5 Curcumin: Potential for Combination Therapy 195
15.5.1 Curcumin with Xanthorrhizol 196
15.5.2 Curcumin with Docosahexaenoic Acid (DHA, Polyunsaturated Fatty Acids Present in Fish Oil) 196
15.5.3 Curcumin and Genistein 196
15.5.4 Curcumin and Resveratrol 197
15.5.5 Curcumin and EGCG 197
15.5.6 Curcumin and Citrus Limonoids 197
15.5.7 Curcumin with Apigenin 197
15.5.8 Curcumin and Triptolide 198
15.5.9 Combinations of Curcumin with Conventional Cancer Chemotherapeutics 198
15.6 Resveratrol: Potential for Combination Therapy 199
15.6.1 Resveratrol and Genistein 199
15.6.2 Resveratrol and Piperine 200
15.6.3 Resveratrol and Black Tea Polyphenols 200
15.6.4 Resveratrol and Melatonin 200
15.6.5 Synergism among Resveratrol and Other Grapes’ Polyphenols 200
15.6.6 Resveratrol in Combination with Anticancer Drugs 201
15.7 Lycopene (a Carotenoid): Potential for Combinations Therapy 202
15.7.1 Lycopene and Genistein 202
15.7.2 Lycopene and Sc-allyl Cysteine 202
15.7.3 Lycopene and 1,25-Dihydroxyvitamin D3 202
15.7.4 Lycopene with Selenium 203
15.7.5 Lycopene and FruHis (Ketosamine) 203
15.7.6 Combination of Lycopene with Cancer Chemotherapeutic Drugs 203
15.8 Soy Nutraceuticals: Potential for Combination Therapy 203
15.8.1 Genistein and Daidzein 203
15.8.2 Genistein and 3,3’-Diindolylmethane 203
15.8.3 Genistein and Capsaicin 204
15.8.4 Combination of Genistein with Conventional Cancer Chemotherapeutics 204
15.9 Tea Polyphenols Potential for Combinatorial Therapy 204
15.9.1 Green Tea and Quercetin 205
15.9.2 EGCG and Soy Phytochemical 205
15.9.3 EGCG and Thymoquinone 205
15.9.4 EGCG and Trichostatin A 205
15.9.5 EGCG and Luteolin 205
15.9.6 EGCG and Pterostilbene (a Stilbenoid Derived from Blueberries) 205
15.9.7 EGCG and Panaxadiol 206
15.9.8 Polyphenon E 206
15.9.9 EGCG with Conventional Cancer Chemotherapy 206
15.10 D-Limonene: Potential for Combination Therapy 207
15.10.1 D-Limonene and Chemotherapeutic Drugs 207
15.11 Miscellaneous: Novel Nutraceuticals Formulation 207
15.11.1 Coltect: A Dietary Supplement 207
15.11.2 BreastDefend: A Natural Dietary Supplement 208
15.11.3 ProstaCaid: A Dietary Supplement 208
15.12 Conclusion 208
References 208
16 Nutrigenomic Approaches to Understanding the Transcriptional and Metabolic Responses of Phytochemicals to Diet-Induced Obesity and its Complications 218
Myung-Sook Choi and Eun-Young Kwon
16.1 Introduction 218
16.2 Nutrigenomics 219
16.2.1 Tools for Bioinformatics and Systems Biology 219
16.3 Obesity and Cardiometabolic Syndrome 222
16.3.1 Obesity 222
16.3.2 Inflammation and Insulin Resistance in Obesity 223
16.3.3 Obesity and Cardiometabolic Syndrome: A Possible Role for Nutrigenomics 224
16.4 Anti-Obesity Action of Luteolin 225
16.5 Conclusion 226
Acknowledgments 226
References 226
17 Going Beyond the Current Native Nutritional Food Through the Integration of the Omic Data in the Post-Genomic Era: A Study in (Resistant) Starch Systems Biology 230
Treenut Saithong and Saowalak Kalapanulak
17.1 Introduction 230
17.2 Starch and its Yield Improvement in Plants 231
17.3 An Extension of the (Resistant) Starch Yield Improvement Research on the Systems Biology Regime: Integration of the Omic Data from the Post-Genomic Technology 233
References 239
Part III Proteomics 243
18 Proteomics and Nutrition Research: An Overview 245
Arun K. Tewari, Sudhasri Mohanty, and Sashwati Roy
18.1 Introduction 245
18.2 Proteomics 245
18.2.1 Proteomics Tools and Technologies 246
18.3 Nutrition and Proteins 246
18.4 Nutritional Biomarkers 248
18.5 Nutritional Bioactives 248
18.5.1 Wheat Proteins 248
18.5.2 Vitamins 248
18.5.3 Glucose 249
18.5.4 Wine and Soy Nutrients 249
18.6 Diet-Based Proteomics Application to Animal Products (Livestock Applications) 249
18.7 Proteomics and Food Safety 249
18.8 Conclusion 249
18.9 Significance 250
Conflict of Interests 250
References 250
19 Proteomics Analysis for the Functionality of Toona sinensi
