Bochkarev / Polyakova Processes of Formation of Micro -and Nanodispersed Systems

Erscheinungsjahr 2015
ISBN: 978-1-4822-5146-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 474 Seiten

Capillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Chip-Capillary Electrophoresis Devices broadens the scope of chemical analysis, particularly in the biomedical, food, and environmental sciences.

The book gives an overview of the development of MC and CE technology as well as technology that now allows for the fabrication of MC-CE devices. It describes the operating principles that make integration possible and illustrates some achievements already made by the application of MC-CE devices in hospitals, clinics, food safety, and environmental research. The authors envision further applications for private and public use once the proof-of-concept stage has been passed and obstacles to increased commercialization are addressed.

A summary of the current methodology and application of MC-CE devices, including their merits, limitations, and potential, closes the book. It highlights the path to be taken for future development of MC-CE and anticipates new advances in technology that will increase their performance and use as powerful analytical tools. With enhanced power, their scope of applications will widen and yield new benefits to researchers and the general public.

Autoren/Hrsg.

Bochkarev, A. A.

Polyakova, V. I.

Fachgebiete

• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Maschinenbau Mechatronik, Mikrosysteme (MEMS), Nanosysteme
• Naturwissenschaften Chemie Physikalische Chemie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde

Inhaltsverzeichnis

Microfluidic Chip-Capillary Electrophoresis: Expanding the Scope of Application for On-Site Analysis of Difficult Samples
Ying Sing Fung

Instrumentation and Facilities I: Fabrication of Microfluidic Chip-Capillary Electrophoresis Device
Wenpeng Guo

Instrumentation and Facilities II: Manipulating Nanofluids for Desired Operations to Achieve Intended Application by MC-CE Device
Ruige Wu, Zhou Nie, and Ying Sing Fung

Single-Channel Mixing: Extending Analytical Range to Handle Samples with High Analyte Variation for Profiling Urinary Organic and Inorganic Anions
Wenpeng Guo

Dual-Channel Mixing: Standard Addition by Dual-Channel Continuous Flow Mixing for Assay of Complex Nephrolithiasis Biomarkers in Urine
Wenpeng Guo

Sample Cleanup and Analyte Enrichment: Integrating MIP/SPE with ME-MC-CE Device to Enhance Sample Cleanup and Multidimensional Analyte Enrichment for Hourly Determination of Atmospheric Carbonyl Compounds
Hui Sun and Ying Sing Fung

Enhancing Separation Efficiency: On-Chip Multidimensional Separation and Determination of Urinary Proteins by MC-CE Device
Ruige Wu and Ying Sing Fung

Improving Detection Selectivity: MC-CE Device Integrated with Dual Opposite Carbon-Fiber Microdisk Electrodes Detection for Determining Polyphenols in Wine
Fuying Du and Ying Sing Fung

Enhancing Detection Versatility: MC-CE Device with Serial Dual-Electrode Detection for Determining Glutathione Disulfide and Glutathione in Pharmaceutical Supplement
Fuying Du and Ying Sing Fung

Detecting Optically Inactive Analyte: MC-CE Device Integrated with QDs/LIF Detection for Determination of Acrylamide in Food
Qidan Chen and Ying Sing Fung

Quantum Dots-Enhanced Fluorescence Detection: Immobilized Quantum Dots for Laser-Induced Fluorescence Detection of Organophosphorus Pesticides in Vegetables
Qidan Chen and Ying Sing Fung

On-Site Assay by Portable UV Detector: MC-CE Device for Authenification of Chinese Medicine
Zhou Nie and Ying Sing Fung

On-Chip Binding Assay: MC-CE Device Integrated with Multisegment Circular-Ferrofluid-Driven Micromixing Injection for Assay of Free Bilirubin and Albumin Residual Binding Capacity for Bilirubin
Zhou Nie and Ying Sing Fung

Counting Organelles: Direct Counting of Mitochondrial Numbers
Wenfeng Zhao and Ying Sing Fung

Indirect Assessment of Organelles in Cell Extract: Determination of Mitochondrial Number by Cardiolipin Content Using MC-CE Device Integrated with Laser-Induced Fluorescence
Wenfeng Zhao and Ying Sing Fung

Protein Characterization and Quantitation: Integrating MC-CE Device with Gas-Phase Electrophoretic Mobility Molecular Analyzer
Tongmei Ma, Gloria K. L. Sze, and Ying Sing Fung

Current Achievements and Future Perspectives
Ying Sing Fung

Appendix I: Definition of Commonly Used Microfluidic Devices

Appendix II: Suppliers for Multi-High-Voltage Power Systems, Portable CE Instrumentation, and Associated High-Voltage Accessories

Über Autor(innen)

Dr. Ying Sing Fung received his BSc and MPhil from the University of Hong Kong, Hong Kong SAR, China, in 1975 and 1977, respectively, and his PhD from the Imperial College of Science, Technology and Medicine, University of London, United Kingdom, in 1980. He is currently associate professor in the Department of Chemistry at the University of Hong Kong. He has been a member of the editorial board of Journal of Chemical Education (Chinese Chemical Society) and Journal of Biochemical and Biophysical Methods (Elsevier Science, the Netherlands). He holds four patents and has authored or co-authored 12 books and reviews, more than 130 journal articles, and 290 conference papers.

Dr. Qidan Chen received her PhD from the University of Hong Kong, Hong Kong SAR, China, in 2010. She is associate professor at Zhuhai College, Jilin University. Her research interests include the application of nanomaterial in microfluidic-chip capillary electrophoresis (MC-CE) devices and in food testing research, using various international advanced technologies based on semiconductor nanoparticles, microfluidic electrophoresis devices, and laser fabrication techniques, and the development of novel analytical methodology for the determination of toxic environmental pollutants and new analytical methods for the determination of contaminants in food. She has more than 20 publications in journals and presentations at international conference proceedings. She is a co-editor of this book and the principal author of chapters 10 and 11.

Dr. Fuying Du received her PhD from the University of Hong Kong, Hong Kong SAR, China, in 2012. She took a postdoctoral position in the Department of Water Quality Engineering, Wuhan University for two years prior to appointment to her current position as a lecturer in the Department of Water Quality Engineering, Wuhan University. Her research interests include electrochemical sensor and electrochemical biosensor for water analysis, and semiconductor photocatalysts for hydrogen evolution from water splitting. She is a co-editor of this book and the principal author of chapters 8 and 9.

Dr. Wenpeng Guo received his PhD from the University of Hong Kong, Hong Kong SAR, China, in 2011. He is associate professor in the First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Shenzhen, People’s Republic of China, and also academic advisor to Hubei University of Chinese Medicine, Wuhan. He was appointed as committee member of the Guangdong Association of the Integrative Traditional and Western Medicine and as the English editor of Shenzhen Journal of Integrated Traditional Chinese and Western Medicine. His research interests include the development of microfluidic chip-capillary electrophoresis devices for biomedical and clinical application and on clinical integrative research of traditional and Western medicine. He holds 18 patents, has authored or co-authored 2 books and reviews, and has published more than 15 journal articles. He is a co-editor of this book and the principal author of chapters 2, 4, and 5.

Dr. Gloria Kwan-lok SZE received her PhD from the University of Hong Kong, Hong Kong SAR, China, in 2009. She worked in the R&D Department at Bureau Veritas HK Ltd. (Hong Kong SAR) in 2010 prior to joining the Government Laboratory in 2012 as a chemist. Her research interest is focused on protein characterization using MC-CE devices integrated with Gas-phase Electrophoretic Mobility Molecular Analyzer (GEMMA). She is the author of chapter 16 of this book.

Dr. Tongmei Ma received her PhD from the University of Hong Kong, Hong Kong SAR, China, in 2005, and took up a postdoctoral position in Arizona State University, Tempe, Arizona. Since 2009 she has joined the South China University of Technology, Guangzhou, China. Her research interests include spectral studies on transition metal containing molecules, transition metal clusters, protein molecules, atmospheric pollutants, and others by employing various modern experimental methods combined with theoretical calculations. She is the author of more than 50 journal and conference papers. She is a co-editor of this book and the principal author of chapter 16.

Dr. Zhou Nie received his PhD from the University of Hong Kong, Hong Kong SAR, China, in 2008. After graduation he joined the SGS R&D Department (Shatin, Hong Kong) from 2009 to 2010. During this period, he had developed and validated new testing methods to meet requirements for environment and safety regulation. Since 2010 he has worked in Amway China (Guangzhou, Guangdong Province, China) focusing on quality control of botanical extracts in health foods for the Chinese market. His current interest is developing microfluidic chip-capillary electrophoresis devices for on-site quality assessment of traditional Chinese medicine and related herbal extract and for determining the binding capacity of bilirubin with human serum proteins. He is a co-editor and the principal author of chapters 12 and 13 of this book.

Dr. Hui Sun received her PhD from the University of Hong Kong, Hong Kong SAR, China, in 2006. From 2006 to 2010, she worked as research associate for postdoctoral research work in the department of chemistry at the University of Hong Kong. She is currently associate professor in the College of Environmental Science & Engineering, Guangzhou University, Guangzhou, People’s Republic of China. Her research interests include microfluidic chip-capillary electrophoresis devices for environmental, biomedical, and food safety application, and chemical sensors and biosensors based on the piezoelectric quartz crystal technology. She holds three patents, and has authored one book and more than 50 journal and conference papers. She is a co-editor and principal author of chapter 6 of this book.

Dr. Ruige Wu received her PhD on microfluidics applications in analytical chemistry from the University of Hong Kong, Hong Kong SAR, China, in 2011. She is currently a scientist of Singapore Institute of Manufacturing Technology (SIMTech, A*Star), Singapore. Her research interests include the applications of microfluidic technology on biomedical and biological areas. She is a co-editor and co-principal author of chapters 3 and 7 of this book.

Dr. Wenfeng Zhao received her PhD from the University of Hong Kong, Hong Kong SAR, China, in 2010. She is associate professor in the School of Chemical and Engineering, Jiangsu Normal University, Xuzhou, People’s Republic of China. Her research interests include microfluidic chip-capillary electrophoresis devices for biomedical nanoparticles analysis and single molecule detection. She holds a patent and has authored more than 20 journal and conference papers. She is a co-editor and the principal author of chapters 14 and 15 of this book.