Bock / Cardew Transport and Trafficking in the Malaria-Infected Erythrocyte

1. Auflage 2008
ISBN: 978-0-470-51574-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 304 Seiten, E-Book

Reihe: Novartis Foundation Symposium

There is an urgent need to uncover new therapies that will protectagainst malaria, as the parasite becomes increasingly resistant toavailable drugs and this book offers insights into threeinterrelated aspects of the malaria-infected erythrocyte:
* The transport of solutes into and out of the infected cell andthe use of specific trafficking pathways in drug targeting
* The traffic of proteins produced by the intracellular parasite asan essential process for the biogenesis of transport systems.
* The relationship between the transport of drugs into the infectedcell and the mode of drug action and drug resistance.

Autoren/Hrsg.

Bock, Gregory R.

Cardew, Gail

Inhaltsverzeichnis

Introduction: host-parasite interrelations in the genomic age
H. GINSBURG
Erythrocyte membrane transport
Z. I. CABANTCHIK
Chemical and physical in vitro alterations of the erythrocytemembrane: a model for its pathophysiological states?
B. DEUTICKE
The effects of transport perturbations on the homeostasis of redblood cells
V. LEW and A.R. HOCKADAY
Transport properties of the host cell membrane
K. KIRK, H.M. STAINES, R.E. MARTIN and K.J. SALIBA
Transport of phospholipid synthesis precursors and lipidtrafficking into malaria-infected erythrocytes
H.J. VIAL, P. ELDIN, D. MARTIN, L. GANNOUN, M. CALAS and M.L.ANCELIN
A nutrient-permeable channel on the intraerythrocytic malariaparasite
S.A. DESAI
The permeability properties of the parasite cell membrane
H. GINSBURG
Macromolecular transport in malaria-infected erythrocytes
T. F. TARASCHI
Expression of parasite transporters in Xenopus oocytes
S. KRISHNA and C.J. WOODROW
Reconstitution of protein transport across the vacuolar membranein Plasmodium falciparum-infected permeabilized erythrocytes
S. BAUMEISTER, A. BURGWEDEL, U.-G. MAIER and K. LINGELBACH
Export of parasite proteins to the erythrocyte cytoplasm:secretory machinery and signalling motifs
F.R. ALBANO, M. FOLEY and L. TILLEY
Transport and trafficking: Toxoplasma as a model forPlasmodium
D.S. ROOS, M.J. CRAWFORD, R.G.K. DONALD, L.M. FOHL, K.M. HAGER,J.C. KISSINGER, M.G. REYNOLDS, B. STREIPEN and W.J. SULLIVAN Jr
An alternative secretory pathway in Plasmodium: more questionsthan answers
M.F. WISER, D.J. GRAB, and H.N. LANNERS
The transport of the histidine-rich protein I from Plasmodiumfalciparum is insensitive to brefeldin A
D. MATTEI, L. BERRY, S. COUFFIN and O. RICHARD
Protein transport in the host cell cytoplasm and ATP-bindingcassette proteins in Plasmodium falciparum-infectederythrocytes
Z. BOZDECH and E. SCHURR
Chloroquine uptake and activity is determined by binding toferriprotoporphyrin IX in Plasmodium faciparum
P.G. BRAY, O. JANNEH and S.A. WARD
Chloroquine uptake, altered partiitioning and the basis of drugresistance: evidence for chloride dependent ionic regulation
J.A. MARTINEY, A.S. FERRER, A. CERAMI, S. DZEKUNOV and P.ROEPE