Bock / Goode 'In Silico' Simulation of Biological Processes

1. Auflage 2003
ISBN: 978-0-470-85790-8
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 270 Seiten, E-Book

Reihe: Novartis Foundation Symposia

Over recent decades vast amounts of biological data have beenaccumulated. However, it is becoming increasingly difficult toapply traditional theoretical methods to the formulation ofcoherent pictures of cell and organ function because it is nolonger possible for a human theorist to integrate all of theavailable information. Instead, computer technologies must now beused to perform this integration. This book brings togethercontributions from many different fields to summarize the currentstatus of computer-assisted modelling of biological processes.
The initial chapters deal with fundamental developments inhardware, software and mathematics that underlie current approachesto biological modelling. Next, different approaches to collatingdata on gene structure and function are presented. These databasesform a vital resource for any investigator trying to construct anintegrated picture of particular biological systems.
Cell signalling systems form a particularly complicated aspectof all cellular function and are important both in theunderstanding of basic cellular processes and in selecting targetsfor drugs. Recent approaches to integrating data on cell signallinginto computer models are covered. Further chapters build on theseapproaches to show how computerized models of intact cells can bedeveloped. Finally, approaches to the computer modelling of wholeorgans such as the heart are presented. The role of computermodelling in drug design is the subject of the final chapter and isalso touched on throughout the discussions.

Autoren/Hrsg.

Bock, Gregory R.

Goode, Jamie A.

Inhaltsverzeichnis

Chair's Introduction (D. Noble).
Integrative biological modelling in silico (A. McCullochand G. Huber).
Advances in computing, and their impact on scientific computing(M. Giles).
From physics to phenomenology: Levels of description and levelsof selection (D. Krakauer).
Making sense of complex phenomena in biology (P. Maini).
On ontologies for biologists: the Gene Ontology--untanglingthe web (M. Ashburner and S. Lewis).
General discussion I: Model validation.
The KEGG database (M. Kanehisa).
Shanka Subramaniam and the Bioinformatics Core LaboratoryBioinformatics of cellular signalling.
General discussion II: Standards of communication.
Semantics and intercommunicability.
Imaging-based integrative models of the heart: closing the loopbetween experiment and simulation (R. Winslow, et al.).
General discussion III: Modelling Ca¯2+signalling.
The Virtual Cell project (L. Loew).
Modelling the bacterial chemotaxis receptor complex (T. Shimizuand D. Bray).
The heart cell in silico: successes, failures andprospects (D. Noble).
General discussion IV.
The IUPS Physiome Project (P. Hunter, et al.).
Using in silico biology to facilitate drug development(J. Levin, et al).
Final discussion: Is there a theoretical biology?
Index of contributors.
Subject index.