Bodanszky Principles of Peptide Synthesis

Erscheinungsjahr 2012
ISBN: 978-3-642-96763-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 308 Seiten, Web PDF

Reihe: Chemistry and Materials Science

A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.

Zielgruppe

Research

Autoren/Hrsg.

Bodanszky, M.

Inhaltsverzeichnis

I. Introduction.- References of Chapter 1.- II. Activation and Coupling.- A. Activation.- B. Coupling.- C. Coupling Methods.- References of Chapter II.- III. Reversible Blocking of Amino and Carboxyl Groups.- A. General Aspects.- B. Protection of the Carboxyl Group.- C. Protection of the Amino Group.- References of Chapter III.- IV. Semipermanent Protection of Side Chain Functions.- A. Carboxyl Groups of Aspartyl and Glutamyl Residues.- B. Side Chain Amino Groups of Lysine and Ornithine.- C. Hydroxyl Groups in Serine, Threonine and Tyrosine.- D. The Sulfhydryl Group in Cysteine.- E. The Guanidino Group of Arginine.- F. Imidazole in Histidine.- G. The Thioether in Methionine.- H. The Indole Nitrogen in Tryptophan.- I. The Carboxamide Groups in Asparagine and Glutamine.- References of Chapter IV.- V. Side Reactions in Peptide Synthesis.- A. Side Reactions Initiated by Proton Abstraction.- B. Side Reactions Initiated by Protonation.- C. Side Reactions Due to Overactivation.- D. Side Reactions Related to Individual Amino Acid Residues.- References of Chapter V.- VI. Tactics and Strategy in Peptide Synthesis.- A. Tactics.- B. Strategies.- C. Disulfide Bridges.- D. Synthesis of Cyclic Peptides.- E. Sequential Polypeptides.- F. Partial Synthesis (Semisynthesis).- References of Chapter VI.- VII. Techniques for the Facilitation of Peptide Synthesis.- A. Solid Phase Peptide Synthesis (SPPS).- B. Synthesis in Solution.- References of Chapter VII.- VIII. Recent Developments and Perspectives.- A. Formation of the Peptide Bond.- B. Protection.- C. Side Reactions.- D. Solid Phase Peptide Synthesis.- E. Catalysis..- References of Chapter VIII.- Author Index.