Cardew Gap Junction-Mediated Intercellular Signalling in Health and Disease

1. Auflage 2008
ISBN: 978-0-470-51559-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 296 Seiten, E-Book

Reihe: Novartis Foundation Symposia

Gap junctions are key elements in communication between cells inmulticellular organisms. It is clear that their activityis essential for normal embryonic development and normal functionin adult organs, although the individual roles of the proteins thatform the channels (connexins) are not yet fully understood.
The last few years have seen considerable progress in this fieldand exciting new issues concerning gap junctional intercellularcommunication are being raised. Perturbed gap junctionactivity is beginning to be linked to certain pathologies,e.g. mutations in the major connexin of the heart have beenfound in human patients suffering from visceroatrial heterotaxiasyndrome and mutations in the gene encoding another connexin havebeen found in patients with Charcot-Marie-Tooth disease.
This book is the first to highlight the recent progress inunderstanding gap junction structure and to discuss the specificroles of individual connexins. It features contributions from aninterdisciplinary group of experts who review the role of gapjunctions in the heart, the retina and lens, the auditory system,the reproductive system, and in cell proliferation and cancer.
The book will appeal to people interested in cell andmolecular biology, embryonic development, neurobiology, cardiology,gynaecology and oncology.

Autoren/Hrsg.

Cardew, Gail

Inhaltsverzeichnis

Molecular Biology of the Interactions Between Connexins (N.Kumar).
Electron Cryo-Crystallography of a Recombinant Cardiac Gap JunctionChannel (V. Unger, et al.).
Trafficking Pathways Leading to the Formation of Gap Junctions (W.Evans, et al.).
Interactions Between Growth Factors and Gap JunctionalCommunication in Developing Systems (A. Warner).
Biological Functions of Connexin Genes Revealed by Human GeneticDefects, Dominant Negative Approaches and Targeted Deletions in theMouse (K. Willecke, et al.).
Connexins in the Lens: Are They to Blame in DiabeticCataractogenesis? (J. Kistler, et al.).
Neuronal Coupling in the Central Nervous System: Lessons from theRetina (D. Vaney).
Gap Junctions and Connexin Expression in the Inner Ear (A. Forge,et al.).
Gap Junction-Mediated Communication in the Developing and AdultCerebral Cortex (B. Nadarajah & J. Parnavelas).
The Role of the Gap Junction Protein Connexin32 in the Pathogenesisof X-linked Charcot-Marie-Tooth Disease (S. Scherer, et al.).
Cardiovascular Disease (N. Severs).
Misregulation of Connexin43 Gap Junction Channels and CongenitalHeart Defects (C. Dasgupta, et al.).
Gap Junctional Intercellular Communication in the Mouse OvarianFollicle (D. Goodenough, et al.).
Connexins in Tumour Suppression and Cancer Therapy (H. Yamasaki, etal.).
Summary.
Indexes.